This review addresses the possible consequences of a mismatch in length between the
hydrophobic part of membrane-spanning proteins and the hydrophobic bilayer thickness for …

Fibrillar protein deposits (amyloid) in the pancreatic islets of Langerhans are thought to be
involved in death of the insulin-producing islet β cells in type 2 diabetes mellitus. It has been …

We have investigated the effect of several hydrophobic polypeptides on the phase behavior
of diacylphosphatidylcholines with different acyl chain length. The polypeptides are …

Membrane proteins present a hydrophobic surface to the surrounding lipid, whereas portions
protruding into the aqueous milieu expose a polar surface. But how have proteins evolved …

… Preliminary experiments in our lab (Koorengevel, Scheidelaar and Killian, unpublished
results) indicate that vesicles of longer lipids require larger amounts of SMA to form nanodiscs. …

Specific interactions of membrane proteins with the membrane interfacial region potentially
define protein position with respect to the lipid environment. We investigated the proposed …

We measured the lateral mobility of integral membrane proteins reconstituted in giant unilamellar
vesicles (GUVs), using fluorescence correlation spectroscopy. Receptor, channel, and …

A major obstacle in the study of membrane proteins is their solubilization in a stable and
active conformation when using detergents. Here, we explored a detergent-free approach to …

… and Killian, JA, 1999, Different membrane anchoring positions of tryptophan and lysine in …
and Killian, JA, 2002, Influence of hydrophobic mismatch and palmitoylation on the association …

Nonbilayer lipids can be defined as cone-shaped lipids with a preference for nonbilayer
structures with a negative curvature, such as the hexagonal phase. All membranes contain …