Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties

…, A Raz, MS Minkes, JA Ferrendelli… - Proceedings of the …, 1979 - National Acad Sciences
Platelets enzymatically convert prostaglandin H 3 (PGH 3 ) into thromboxane A 3 . Both
PGH 2 and thromboxane A 2 aggregate human platelet-rich plasma. In contrast, PGH 3 and …

Interruption of the mammillothalamic tract prevents seizures in guinea pigs

MA Mirski, JA Ferrendelli - Science, 1984 - science.org
Interruption of the connection between the mammillary bodies and the anterior nucleus of
the thalamus in guinea pigs, by discrete bilateral electrolytic lesions of the mammillothalamic …

Anterior thalamic mediation of generalized pentylenetetrazol seizures

MA Mirski, JA Ferrendelli - Brain research, 1986 - Elsevier
The effects of microinjection of various neuroactive compounds into the anterior thalamic
nucleus (AN) and other selected subcortical regions of guinea pig brain on the expression of …

3, 3-Dialkyl-and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents

…, SM Rothman, JA Ferrendelli… - Journal of medicinal …, 1996 - ACS Publications
A series of 3,3-dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones (lactams) have been
prepared and evaluated for their anticonvulsant activities. In the pentylenetetrazole mouse …

Kainic acid‐induced limbic seizures: Electrophysiologic studies

EW Lothman, RC Collins, JA Ferrendelli - Neurology, 1981 - AAN Enterprises
surface and depth electroencephalograms (EEGs) were studied after intravenous injections
of kainic acid (KA). High frequency oscillations and spikes appeared in the hippocampus at …

Functional anatomy of pentylenetetrazol and electroshock seizures in the rat brainstem

…, AC McKeon, JA Ferrendelli - Annals of Neurology …, 1987 - Wiley Online Library
… , Ferrendelli JA: Interruption of the mammillothalamic tracts prevents seizures in guinea pigs.
Science Mirski MA, Ferrendelli JA: … J Neurosci 7(3):662-670, 1987 Mirski MA, Ferrendelli JA: …

Use of levetiracetam in a population of patients aged 65 years and older: a subset analysis of the KEEPER trial

JA Ferrendelli, J French, I Leppik, MJ Morrell… - Epilepsy & Behavior, 2003 - Elsevier
Levetiracetam (Keppra) was evaluated in a subset of patients aged ⩾65 years (n=78)
enrolled in a large (n=1030) open-label, phase IV trial (the KEEPER trial). A 4-week dose …

Characterization of GABAergic seizure regulation in the midline thalamus

JW Miller, JA Ferrendelli - Neuropharmacology, 1990 - Elsevier
This study characterized the role of GABA in the central medial intralaminar nucleus on seizures
induced by pentylenetetrazol given systemically. Injections of the direct selective GABA …

ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS1

JA Ferrendelli, MM Chang… - Journal of …, 1974 - Wiley Online Library
Guanosine 3′,5’cyclic monophosphate (cyclic GMP) levels in incubated slices of mouse
cerebellum are increased 10‐fold by glutamate and two‐to three‐fold by glycine or γ‐…

Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets.

P Needleman, A Raz, JA Ferrendelli… - Proceedings of the …, 1977 - National Acad Sciences
Human platelet suspensions release a rabbit-aorta-contracting substance (previously identified
as thromboxane A2) during aggregation produced by arachidonic acid, prostaglandin …