Expression of cardiac calcium regulatory proteins in atrium v ventricle in different species

…, P Boknik, LR Jones, U Kirchhefer, J Knapp… - Journal of molecular and …, 1999 - Elsevier
The duration of contraction in isolated electrically driven preparations from atrium and ventricle
of mouse, rat, rabbit, guinea-pig and dog was consistently shorter in atrial compared to …

Protein phosphatase activity is increased in a rat model of long-term β-adrenergic stimulation

P Boknik, M Fockenbrock, S Herzig, J Knapp… - Naunyn-Schmiedeberg's …, 2000 - Springer
We tested the hypothesis that altered phosphorylation of Ca 2+ regulatory proteins contributes
to contractile anomalies in cardiac hypertrophy. Cardiac hypertrophy was induced in rats …

Regional expression of phospholamban in the human heart

…, U Kleideiter, O Klein-Wiele, J Knapp… - Cardiovascular …, 1999 - academic.oup.com
Background: Several independent lines of evidence indicate that phospholamban (PLB)
expression correlates positively with depression of force of contraction and duration of …

Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart

…, O Klein-Wiele, P Boknı́k, S Herzig, J Knapp… - Journal of molecular and …, 2000 - Elsevier
In mammalian species, including man, the duration of myocardial contraction is shorter in
atria than ventricles. Total contraction time depends at least in part on phosphorylation and …

Contractility and inhibition of protein phosphatases by cantharidin

J Knapp, P Boknı́k, S Huke, I Gombosová… - … : The Vascular System, 1998 - Elsevier
Cantharidin is a natural defensive toxicant produced by blister beetles. 2. Cantharidin
shares structural similarity with highly toxic commercial herbicides (eg, endothall, endothall …

Postnatal changes in contractile time parameters, calcium regulatory proteins, and phosphatases

…, P Bokník, U Kirchhefer, J Knapp… - American Journal …, 1998 - journals.physiology.org
Compared with isolated electrically driven neonatal ventricular preparations, the total time of
contraction, the time to peak tension, and the time of relaxation were decreased to ∼50% in …

Enhanced protein phosphorylation in hypertensive hypertrophy

…, U Kirchhefer, J Knapp… - Cardiovascular …, 2001 - academic.oup.com
Objective: Chronic pressure overload in spontaneously hypertensive rats (SHR) is accompanied
by heart hypertrophy and signs of heart failure. Since there is growing evidence for a …

Role of protein phosphatases in regulation of cardiac inotropy and relaxation

…, GS Bodor, S Huke, J Knapp… - American Journal …, 2001 - journals.physiology.org
We studied the effects of the protein phosphatase (PP) inhibitor cantharidin (Cant) on time
parameters and force of contraction (FOC) in isometrically contracting electrically driven …

Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes

FU Müller, P Bokník, J Knapp, B Linck… - Cardiovascular …, 2001 - academic.oup.com
Objective: Chronic β-adrenergic stimulation of the cAMP-dependent signalling pathway is
implicated in functionally relevant expressional changes in congestive heart failure. We …

Long-term beta adrenoceptor-mediated alteration in contractility and expression of phospholamban and sarcoplasmic reticulum Ca++-ATPase in mammalian ventricle

…, E Jäckel, LR Jones, U Kirchhefer, J Knapp… - … of Pharmacology and …, 1998 - ASPET
We studied the influence of prolonged administration of thebeta adrenoceptor agonist
isoproterenol on contractile parameters and expression of sarcoplasmic reticulum (SR) Ca ++ -…