3, Clinical use of valproate 317 3.1. Epilepsy 317 3.1. 1. Primary generalised seizures 317
3.1. 2. Partial seizures 319 3.1. 3. Status epilepticus 319 3.1. 4. Prophylaxis of febrile …

The limbic localization of the arginine vasopressin V 1b receptor has prompted speculation
as to a potential role of this receptor in the control of emotional processes. To investigate this …

Benzodiazepines are widely used anxiolytics and anticonvulsants, and their potent sedative
properties are routinely used in presurgical anaesthesia. However, they are also known to …

SR 141716 (1 and 3 mg/kg po), a selective central (CB1) cannabinoid receptor antagonist,
selectively reduced feeding of a very highly palatable cane-sugar mixture in marmosets. In …

The complexity of the stress response would appear to provide multiple opportunities for
intervention, but treatment strategies are often centered on the improvement of symptoms rather …

(2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine
carboxamide (SSR149415), the first …

SL651498 (6‐fluoro‐9‐methyl‐2‐phenyl‐4‐(pyrrolidin‐1‐yl‐carbonyl)‐2, 9‐dihydro‐1H‐pyrido[3,4‐b]indol‐1‐one)
was identified as a drug development candidate from a research …

The present study investigated the effects of the novel corticotrophin-releasing factor (CRF)
1 receptor antagonist 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-…

The staircase test consists of placing a naive mouse in an enclosed staircase with five steps
and observing the number of steps climbed and rearings made in a 3-min period. All the …

A new potent, selective and po active serotonergic [5-hydroxytryptamine (5-HT2)] receptor
antagonist, SR 46349B [trans, 4-([3Z)3-(2-dimethylaminoethyl)oxyimino-3(2-flurophenyl++ +)…