… of full-length TERT, suggesting that DKC cancers do not necessarily require an ALT
pathway for telomere maintenance (JR Mitchell, J Wong and K Collins, unpublished data). …

The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

The clinical spectrum of isoniazid-induced liver injury seems to be clinically, biochemically,
and histologically indistinguishable from viral hepatitis, except that the injury occurs primarily …

This laboratory has previously postulated that bromobenzene-induced hepatic necrosis
results from the formation of a reactive metabolite that arylates vital cellular macromolecules. …

The possibility that glutathione may protect against acetaminophen-induced hepatic
necrosis was examined. Pretreatment of mice with diethyl maleate, which depletes hepatic …

A number of recent reports indicate that massive overdoses of acetaminophen can produce
a fulminant hepatic necrosis in man. Acetaminophen-induced hepatic necrosis thereforne …

Doses of 3 H-acetaminophen (300-750 mg/kg) that cause necrosis in mice were shown to
result in large amounts of radiolabeled material covalently bound to mouse liver protein in vivo …

We have observed giant magnetoresistance in heterogeneous thin film Cu-Co alloys
consisting of ultrafine Co-rich precipitate particles in a Cu-rich matrix. The magnetoresistance …

Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the
accumulation of senescent cells is thought to drive age-related pathology through a …

To evaluate the relative importance of the medical history, the physical examination, and
laboratory investigations in the diagnosis and management of medical outpatients some …