Chemically induced nephrotoxicity: role of metabolic activation
GF Rush, JH Smith, JF Newton, JB Hook… - CRC critical reviews in …, 1984 - Taylor & Francis
Chloroform (CHCI,, trichloromethane) is a heavy, colorless, volatile liquid at room temperature
and pressure. CHCI, is highly lipophilic (olive oil/air= 401) and was a majoi anesthetic in …
and pressure. CHCI, is highly lipophilic (olive oil/air= 401) and was a majoi anesthetic in …
Simultaneous Determination of Δ9-Tetrahydrocannabinol and 11-nor-9-Carboxy-Δ9-Tetrahydrocannabinol in Human Plasma by Solid-Phase Extraction and Gas …
…, RL Foltz, MA Huestis, JF Newton - Journal of Analytical …, 2001 - academic.oup.com
Δ 9 -Tetrahydrocannabinol (THC) and 11-nor-Δ 9 -carboxy-Δ 9 -tetrahydrocannabinol (THCA)
in human plasma can be simultaneously detected using solid-phase extraction with gas …
in human plasma can be simultaneously detected using solid-phase extraction with gas …
The East Greenland polar front in autumn
RG Paquette, RH Bourke, JF Newton… - Journal of …, 1985 - Wiley Online Library
… Considerable definition is added to the location of the EGPF and the frontal jet by the present
work and, farther north, by the work of Newton and Piper [1981]. The extension of the jet to …
work and, farther north, by the work of Newton and Piper [1981]. The extension of the jet to …
Metabolism and excretion of a glutathione conjugate of acetaminophen in the isolated perfused rat kidney.
JF Newton, D Hoefle, MW Gemborys, GH Mudge… - … of Pharmacology and …, 1986 - ASPET
Acetaminophen-glutathione (APAP-GSH) is the initial sulfur-containing metabolite of APAP
produced by the liver. However, little, if any, APAP-GSH is found in the urine of intact animals. …
produced by the liver. However, little, if any, APAP-GSH is found in the urine of intact animals. …
Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat
JF Newton, CH Kuo, MW Gemborys, GH Mudge… - Toxicology and applied …, 1982 - Elsevier
Acetaminophen (APAP) produces proximal tubular necrosis in the Fischer 344 rat. APAP is
deacetylated to p-aminophenol (PAP) in the hamster, and PAP has been reported to be a …
deacetylated to p-aminophenol (PAP) in the hamster, and PAP has been reported to be a …
Acetaminophen nephrotoxicity in the rat: I. Strain differences in nephrotoxicity and metabolism
JF Newton, M Yoshimoto, J Bernstein, GF Rush… - Toxicology and applied …, 1983 - Elsevier
Acetaminophen (APAP) produced renal necrosis restricted to the straight segment of the
proximal tubule in Fischer 344 (F344) rats but not in Sprague-Dawley (SD) rats. APAP-induced …
proximal tubule in Fischer 344 (F344) rats but not in Sprague-Dawley (SD) rats. APAP-induced …
[BOOK][B] The Return to Nature: Or, A Defence of the Vegetable Regimen; with Some Account of an Experiment Made During the Last Three Or Four Years in the …
JF Newton - 1811 - books.google.com
IT may be thought presumptuous in one unconnected with the profession of medicine, to write
a book on diet, and offer his opinion on the nature of diseases. But having for many years …
a book on diet, and offer his opinion on the nature of diseases. But having for many years …
Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase: Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3 …
…, SJ Schmidt, WR Brian, JF Newton… - Journal of medicinal …, 1996 - ACS Publications
A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase.
Oral activity was established by examining the inhibition of LTB 4 biosynthesis …
Oral activity was established by examining the inhibition of LTB 4 biosynthesis …
[PDF][PDF] Purification, characterization, and structural properties of a single protein from rat basophilic leukemia (RBL-1) cells possessing 5-lipoxygenase and leukotriene …
GK Hogaboom, M Cook, JF Newton, A Varrichio… - Molecular …, 1986 - Citeseer
Arachidonate 5-lipoxygenase of rat basophilic leukemia (RBL-1) cells was purified more
than 1000-fold by gel filtration and anion exchange protein-high performance liquid …
than 1000-fold by gel filtration and anion exchange protein-high performance liquid …
Metabolism and pharmacokinetics of acetaminophen in a severely poisoned young child
MW Lieh-Lai, AP Sarnaik, JF Newton, JN Miceli… - The Journal of …, 1984 - Elsevier
A 1-year-old child with severe acetaminophen (APAP) poisoning after ingestion of 10 gm
APAP demonstrated central nervous system depression, shock, hypothermia, and metabolic …
APAP demonstrated central nervous system depression, shock, hypothermia, and metabolic …