User profiles for J E Malberg

Jessica E. Malberg

Sage Therapeutics
Verified email at myultraworld.com
Cited by 12889

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

JE Malberg, AJ Eisch, EJ Nestler… - Journal of …, 2000 - Soc Neuroscience
Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may
contribute to the pathophysiology of depression. The aim of this study was to investigate the …

[HTML][HTML] Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment

JE Malberg, RS Duman - Neuropsychopharmacology, 2003 - nature.com
Adult hippocampal neurogenesis has been demonstrated in several species and is regulated
by both environmental and pharmacological stimuli. The present study seeks to determine …

Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein

S Nakagawa, JE Kim, R Lee, JE Malberg… - Journal of …, 2002 - Soc Neuroscience
The cAMP cascade, including the cAMP response element-binding protein (CREB), is
known to play an important role in neuronal survival and plasticity. Here the influence of this …

Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects

BA Hoshaw, JE Malberg, I Lucki - Brain research, 2005 - Elsevier
Drug development research has identified neurotrophic factors as a downstream target of
chronic antidepressant treatments. In order to study their antidepressant-like effects, two …

Small changes in ambient temperature cause large changes in 3, 4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body …

JE Malberg, LS Seiden - Journal of Neuroscience, 1998 - Soc Neuroscience
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of
abuse and has been shown to be neurotoxic to 5-HT terminals in many species. MDMA-…

Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications

RH Ring, JE Malberg, L Potestio, J Ping, S Boikess… - …, 2006 - Springer
Rationale Oxytocin (OT) acts as a neuromodulator/neurotransmitter within the central nervous
system (CNS) and regulates a diverse range of CNS functions. Notably, evidence from …

Innovative approaches for the development of antidepressant drugs: current and future strategies

…, CE Beyer, ZA Hughes, X Khawaja, JE Malberg… - NeuroRx, 2005 - Elsevier
Depression is a highly debilitating disorder that has been estimated to affect up to 21% of
the world population. Despite the advances in the treatment of depression with selective …

Implications of adult hippocampal neurogenesis in antidepressant action

JE Malberg - Journal of Psychiatry and Neuroscience, 2004 - jpn.ca
In the dentate gyrus of the hippocampus, cell birth and maturation into neurons, or
neurogenesis, occur throughout the lifetime of animals and humans. Multiple factors have been …

Antidepressant action: to the nucleus and beyond

JE Malberg, JA Blendy - Trends in Pharmacological Sciences, 2005 - cell.com
After decades of effort, the field of depression research is far from understanding how
antidepressant drugs mediate their clinical effects. The time lag of 2–6 weeks of therapy that is …

Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments

DT Balu, BA Hoshaw, JE Malberg… - Brain research, 2008 - Elsevier
Antidepressant treatments have been proposed to produce their therapeutic effects, in part,
through increasing neurotrophin levels in the brain. The current experiments investigated the …