The endomorphin system and its evolving neurophysiological role
J Fichna, A Janecka, J Costentin, JC Do Rego - Pharmacological reviews, 2007 - ASPET
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH 2 ) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH 2 ) are
two endogenous opioid peptides with high affinity and remarkable selectivity for the μ-opioid …
two endogenous opioid peptides with high affinity and remarkable selectivity for the μ-opioid …
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
…, H Mazarguil, G Vassart, M Parmentier, J Costentin - Nature, 1995 - nature.com
THE ORL 1 receptor, an orphan receptor whose human 1 and murine 2-8 complementary
DNAs have recently been characterized, structurally resembles opioid receptors and is …
DNAs have recently been characterized, structurally resembles opioid receptors and is …
[HTML][HTML] Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
…, ME Yacoubi, JJ Vanderhaeghen, J Costentin… - Nature, 1997 - nature.com
… Costentin, J. et al. Dissociated effects of inhibitors of enkephalin-metabolising peptidases …
We thank J.-F. Aubert for his help with the determination ofthe haemodynamic … Jean Costentin …
We thank J.-F. Aubert for his help with the determination ofthe haemodynamic … Jean Costentin …
Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions
P Simon, R Dupuis, J Costentin - Behavioural brain research, 1994 - Elsevier
When mice are introduced into an open-field, they are inclined to explore mainly the
peripheral zone of this open-field. This tendency to remain close the walls, called thigmotaxis, …
peripheral zone of this open-field. This tendency to remain close the walls, called thigmotaxis, …
The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A2A receptors
…, JF Ménard, M Parmentier, J Costentin… - British journal of …, 2000 - Wiley Online Library
The locomotor stimulatory effects induced by caffeine (1,3,7‐trimethylxanthine) in rodents have
been attributed to antagonism of adenosine A 1 and A 2A receptors. Little is known about …
been attributed to antagonism of adenosine A 1 and A 2A receptors. Little is known about …
Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum
P Protais, J Costentin, JC Schwartz - Psychopharmacology, 1976 - Springer
Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls
of their cage. Optimal conditions have been defined to obtain a reliable dose-response …
of their cage. Optimal conditions have been defined to obtain a reliable dose-response …
Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression
…, M Hamon, J Costentin, J Adrien… - Proceedings of the …, 2003 - National Acad Sciences
Depression is a multifactorial illness and genetic factors play a role in its etiology. The
understanding of its physiopathology relies on the availability of experimental models potentially …
understanding of its physiopathology relies on the availability of experimental models potentially …
Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice
…, R Bertorelli, E Ongini, J Costentin… - British journal of …, 2001 - Wiley Online Library
Adenosine, an ubiquitous neuromodulator, and its analogues have been shown to produce ‘depressant’
effects in animal models believed to be relevant to depressive disorders, while …
effects in animal models believed to be relevant to depressive disorders, while …
Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity
…, C Llorens-Cortes, J Costentin… - Proceedings of the …, 2003 - National Acad Sciences
A neuropeptide was isolated from a frog brain extract by HPLC purification and characterized
by mass spectrometry. This 26-aa neuropeptide, which belongs to the RFamide peptide …
by mass spectrometry. This 26-aa neuropeptide, which belongs to the RFamide peptide …
The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A (2A) adenosine receptor antagonists …
…, C Ledent, M Parmentier, J Costentin… - …, 2000 - europepmc.org
Objective Caffeine is well known to promote anxious behaviour in humans and animal
models, but the precise site of action of the drug is still a matter of debate. The present study …
models, but the precise site of action of the drug is still a matter of debate. The present study …