[PDF][PDF] Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

…, M Krummel, BR Stripp, T Vu, ES White, JA Whitsett… - Cell stem cell, 2014 - cell.com
Respiratory disease is the third leading cause of death in the industrialized world. Consequently,
the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive …

Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis

…, GR Dickersin, CJ Bachurski, EL Mark, JA Whitsett… - Science, 1994 - science.org
The in vivo function of murine granulocyte-macrophage colony-stimulating factor (GM-CSF)
was investigated in mice, carrying a null allele of the GM-CSF gene, that were generated by …

[HTML][HTML] A mutation in the surfactant protein C gene associated with familial interstitial lung disease

…, SE Wert, F Askin, A Hamvas, JA Whitsett - … England Journal of …, 2001 - Mass Medical Soc
Interstitial lung diseases are a heterogeneous group of disorders that are poorly understood
at a molecular level. , 2 The cause is often unknown, and the histologic diagnoses used in …

Pulmonary alveolar proteinosis

BC Trapnell, JA Whitsett, K Nakata - New England Journal of …, 2003 - Mass Medical Soc
In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the
alveoli because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar …

Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome.

…, WJ Longmore, MA Moxley, JA Whitsett… - The Journal of …, 1991 - Am Soc Clin Investig
Acute Respiratory Distress Syndrome (ARDS) is characterized by lung injury and damage to
the alveolar type II cells. This study sought to determine if endogenous surfactant is altered …

[HTML][HTML] Respiratory epithelial cells orchestrate pulmonary innate immunity

JA Whitsett, T Alenghat - Nature immunology, 2015 - nature.com
The epithelial surfaces of the lungs are in direct contact with the environment and are subjected
to dynamic physical forces as airway tubes and alveoli are stretched and compressed …

Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.

…, BR Stripp, TE Weaver, JA Whitsett - Proceedings of the …, 1995 - National Acad Sciences
Surfactant protein B (SP-B) is an 8.7-kDa, hydrophobic protein that enhances the spreading
and stability of surfactant phospholipids in the alveolus. To further assess the role of SP-B in …

[HTML][HTML] ABCA3 Gene Mutations in Newborns with Fatal Surfactant Deficiency

…, T Annilo, SE Wert, JA Whitsett… - … England Journal of …, 2004 - Mass Medical Soc
Background Pulmonary surfactant forms a lipid-rich monolayer that coats the airways of the
lung and is essential for proper inflation and function of the lung. Surfactant is produced by …

[HTML][HTML] Bronchopulmonary dysplasia

B Thébaud, KN Goss, M Laughon, JA Whitsett… - Nature reviews Disease …, 2019 - nature.com
In the absence of effective interventions to prevent preterm births, improved survival of infants
who are born at the biological limits of viability has relied on advances in perinatal care …

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

…, JW Tichelaar, MJ Lizak, JA Whitsett… - Genes & …, 2001 - genesdev.cshlp.org
To investigate the role of an activated K-Ras gene in the initiation and maintenance of lung
adenocarcinomas, we developed transgenic mice that express murine K-Ras4b G12D under …