Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway
…, T Gotoh, M Matsumoto, I Wada… - Proceedings of the …, 2001 - National Acad Sciences
Excessive nitric oxide (NO) production in cytokine-activated β cells has been implicated in β
cell disruption in type 1 diabetes. β cells are very vulnerable to NO-induced apoptosis. …
cell disruption in type 1 diabetes. β cells are very vulnerable to NO-induced apoptosis. …
[HTML][HTML] A novel ER α‐mannosidase‐like protein accelerates ER‐associated degradation
N Hosokawa, I Wada, K Hasegawa, T Yorihuzi… - EMBO …, 2001 - embopress.org
The quality control mechanism in the endoplasmic reticulum (ER) discriminates correctly
folded proteins from misfolded polypeptides and determines their fate. Terminally misfolded …
folded proteins from misfolded polypeptides and determines their fate. Terminally misfolded …
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin
Y Oda, N Hosokawa, I Wada, K Nagata - Science, 2003 - science.org
Terminally misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the
cytoplasm and degraded by proteasomes through a mechanism known as ER-associated …
cytoplasm and degraded by proteasomes through a mechanism known as ER-associated …
Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma
…, T Ushiku, S Funahashi, K Tateishi, I Wada… - Nature …, 2014 - nature.com
Diffuse-type gastric carcinoma (DGC) is characterized by a highly malignant phenotype with
prominent infiltration and stromal induction. We performed whole-exome sequencing on 30 …
prominent infiltration and stromal induction. We performed whole-exome sequencing on 30 …
The putative chaperone calmegin is required for sperm fertility
M Ikawa, I Wada, K Kominami, D Watanabe… - Nature, 1997 - nature.com
The proper folding of newly synthesized membrane proteins in the endoplasmic reticulum (ER)
is required for the formation of functional mature proteins. Calnexin is a ubiquitous ER …
is required for the formation of functional mature proteins. Calnexin is a ubiquitous ER …
Human M-ficolin is a secretory protein that activates the lectin complement pathway
…, D Iwaki, M Nakata, M Matsushita, I Wada… - The Journal of …, 2005 - journals.aai.org
Three types of ficolins have been identified in humans: L-ficolin, M-ficolin, and H-ficolin.
Similar to mannose-binding lectin, L-ficolin and H-ficolin are the recognition molecules in the …
Similar to mannose-binding lectin, L-ficolin and H-ficolin are the recognition molecules in the …
[HTML][HTML] EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming
K Hirao, Y Natsuka, T Tamura, I Wada, D Morito… - Journal of Biological …, 2006 - ASBMB
Quality control in the endoplasmic reticulum ensures that only properly folded proteins are
retained in the cell through mechanisms that recognize and discard misfolded or …
retained in the cell through mechanisms that recognize and discard misfolded or …
[HTML][HTML] Enhancement of endoplasmic reticulum (ER) degradation of misfolded Null Hong Kong α1-antitrypsin by human ER mannosidase I
…, LO Tremblay, Z You, A Herscovics, I Wada… - Journal of Biological …, 2003 - ASBMB
Misfolded glycoproteins synthesized in the endoplasmic reticulum (ER) are degraded by
cytoplasmic proteasomes, a mechanism known as ERAD (ER-associated degradation). In the …
cytoplasmic proteasomes, a mechanism known as ERAD (ER-associated degradation). In the …
[HTML][HTML] Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP
N Hosokawa, I Wada, K Nagasawa, T Moriyama… - Journal of Biological …, 2008 - ASBMB
The recognition of terminally misfolded proteins in the endoplasmic reticulum (ER) and the
extraction of these proteins to the cytoplasm for proteasomal degradation are determined by a …
extraction of these proteins to the cytoplasm for proteasomal degradation are determined by a …
Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood–brain-barrier endothelial cells via protein kinase A …
…, T Soma, H Miyajima, K Nagasawa, I Wada… - Experimental cell …, 2003 - Elsevier
Cyclic AMP (cAMP) promotes functions of tight junctions in endothelial cells, although its
target remains unknown. We showed here that cAMP increased gene expression of claudin-5 …
target remains unknown. We showed here that cAMP increased gene expression of claudin-5 …