Involvement of tumor necrosis factor-α in development of hepatic injury in galactosamine-sensitized mice

I Hishinuma, JI Nagakawa, K Hirota, K Miyamoto… - Hepatology, 1990 - journals.lww.com
Intravenous injection of lipopolysaccharide and D-galactosamine, at doses of 0.2 μg/kg and
800 mg/kg, respectively, elicited massive hepatic necrosis within 24 hr in C3H/HeN mice. …

Mechanism of growth promotion of mouse lymphoma L1210 cells in vitro by feeder layer or 2‐mercaptoethanol

T Ishii, I Hishinuma, S Bannai… - Journal of cellular …, 1981 - Wiley Online Library
Mouse lymphoma L1210 cells require some thiol compounds (such as 2‐mercaptoethanol)
or feeder layer cells for their growth in normal culture media in vitro. We found that feeder …

The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs

…, S Suzuki, T Kawahara, A Kajiwara, I Hishinuma - European journal of …, 2011 - Elsevier
Thrombin is a powerful agonist for platelets, the action of which is mediated by the thrombin
receptor protease-activated receptor-1 (PAR-1). Recently, we discovered that E5555 (1-(3-…

[HTML][HTML] Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease

…, Y Ohashi, M Muratani, K Kimura, I Hishinuma… - Nature …, 2018 - nature.com
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a
chronic intestinal inflammatory condition initiated by integrins-mediated leukocyte adhesion to …

Antipruritic effect of the topical phosphodiesterase 4 inhibitor E6005 ameliorates skin lesions in a mouse atopic dermatitis model

…, K Kusano, E Yamamoto, C Inoue, I Hishinuma - … of Pharmacology and …, 2013 - ASPET
Phosphodiesterase (PDE) 4 inhibition is a well-known anti-inflammatory mechanism, but the
development of PDE4 inhibitors has been hampered by side effects such as nausea and …

A novel type of retinoic acid receptor antagonist: synthesis and structure-activity relationships of heterocyclic ring-containing benzoic acid derivatives

…, S Abe, T Hida, S Higashi, I Hishinuma… - Journal of medicinal …, 1995 - ACS Publications
Retinoic acid (RA) is a substance essential for several life processes, including differentiation,
reproduction, hematopoiesis, bone development, and pattern forma-tion during …

A putative antipruritic mechanism of the phosphodiesterase‐4 inhibitor E6005 by attenuating capsaicin‐induced depolarization of C‐fibre nerves

…, M Ohkuro, N Ishii, I Hishinuma… - Experimental …, 2015 - Wiley Online Library
E6005, a potent, selective phosphodiesterase (PDE) 4 inhibitor, has been developed as a
novel topical agent of atopic dermatitis (AD). It has been shown to inhibit itching in patients …

Oral administration of the thrombin receptor antagonist E5555 (atopaxar) attenuates intimal thickening following balloon injury in rats

…, S Suzuki, T Kawahara, A Kajiwara, I Hishinuma - European journal of …, 2011 - Elsevier
Thrombin is a powerful agonist for a variety of cellular responses including platelet aggregation
and vascular smooth muscle cell (SMC) proliferation. These actions are mediated by a …

Mouse lymphoma L1210 cells acquire a new cystine transport activity upon adaptation in vitro

I Hishinuma, T Ishii, H Watanabe, S Bannai - In vitro cellular & …, 1986 - Springer
Mouse lymphoma L1210 cells maintained in vitro at a high cell density for a certain time period
adapted themselves to the in vitro environment and were able to grow indefinitely. From …

[PDF][PDF] Protective effect of E3330, a novel quinone derivative, in galactosamine-induced hepatitis in rats.

J Nagakawa, K Hirota, I Hishinuma, K Miyamoto… - … of Pharmacology and …, 1993 - Citeseer
Materials and Methods Animals. Male Fischer (F344fDuCrj) rats weighing 160 to 190 g were
obtained from Charles River Japan, Inc.(Kanagawa, Japan). The animals were housed …