The occurrence of idiosyncratic adverse drug reactions during late clinical trials or after a
drug has been released can lead to a severe restriction in its use and even in its withdrawal. …

Adults with diabetes have an annual mortality of about 5.4%(double the rate for non-diabetic
adults), and their life expectancy is decreased on average by 5-10 years. Although the …

Many drugs are administered at sites that are remote from their site of action. The most common
route of drug delivery is the oral route. The optimal physicochemical properties to allow …

Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

This work provides a perspective on the qualification and verification of physiologically based
pharmacokinetic (PBPK) platforms/models intended for regulatory submission based on …

… the concept for the volume and approached Iain Gardner to collaborate, especially with
translations of the extensive Coptic corpus. Gardner began to prepare portions of the Kephalaia …

Abstract Development of monoclonal antibodies (mAbs) and their functional derivatives
represents a growing segment of the development pipeline in the pharmaceutical industry. More …

Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential
equations and have been implemented in a number of commercial software packages. …

The Kephalaia of the Teacher is the most detailed account available to modern scholarship
of the teachings of Mani, and of the universal religion that he founded as the final successor …

INTRODUCTION: Safety pharmacology is integral to the non-clinical safety assessment of
new chemical entities prior to first administration to humans. The zebrafish is a well …