Plasticity is a fundamental property of the neural system controlling breathing. One frequently
studied model of respiratory plasticity is long‐term facilitation of phrenic motor output (pLTF…

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease. ALS
selectively causes degeneration in upper and lower (spinal) motor neurons, leading to …

Phrenic long‐term facilitation (pLTF) following acute intermittent hypoxia (AIH) is a form of
spinal, serotonin‐dependent synaptic plasticity that requires reactive oxygen species (ROS) …

Increased levels of interleukin‐6 (IL‐6) play a role in post‐ischemic cerebral inflammation. IL‐6
binding to its receptors induces phosphorylation of the receptor associated janus kinases …

Thiazolidinediones (TZDs) are potent synthetic agonists of the ligand-activated transcription
factor peroxisome proliferator-activated receptor-γ (PPARγ). TZDs were shown to induce …

Thiazolidinediones (TZDs) are synthetic agonists of the ligand‐activated transcription factor
peroxisome proliferator‐activated receptor‐γ (PPARγ). TZDs are known to curtail …

Spinal injury disrupts connections between the brain and spinal cord, causing life-long
paralysis. Most spinal injuries are incomplete, leaving spared neural pathways to motor neurons …

Acute intermittent hypoxia elicits a form of spinal, brain-derived neurotrophic factor (BDNF)-dependent
respiratory plasticity known as phrenic long-term facilitation. Ligands that activate …

Rationale: Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease
causing paralysis and death from respiratory failure. Strategies to preserve and/or restore …

Acute intermittent hypoxia (AIH) initiates plasticity in respiratory motor control, including
phrenic long term facilitation (pLTF). Since pLTF is enhanced by preconditioning with repetitive …