We report here the preclinical profile of etoricoxib (MK-0663) [5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)
pyridine], a novel orally active agent that selectively inhibits …

DFU (5,5‐dimethyl‐3‐(3‐fluorophenyl)‐4‐(4‐methylsulphonyl)phenyl‐2(5H)‐furanone) was
identified as a novel orally active and highly selective cyclo‐oxygenase‐2 (COX‐2) inhibitor. …

In this study, PGE 2 levels in lipopolysaccharide (LPS)-challenged human whole blood and
TxB 2 levels following blood coagulation were measured as biochemical index for …

… Peter Barnes, Ian Rodger and Neil Thomson must be congratulated in drawing together a
group of specialist authors of international standing. Let us hope that their efforts to inform and …

The hypothesis that the neuromuscular blocking potency of pancuronium and vecuronium
depends on the two acetylcholine moieties present at positions 3 and 17 was tested in cats by …

The aim of our study was to characterize the temporal relationship of apoptosis to regional
myocardial ischemia and reperfusion and we aimed to determine the effect of ischemia and …

Objective: To evaluate and compare the efficacy and tolerability of etoricoxib and diclofenac
in patients with osteoarthritis of the knee or hip. Methods: In this 6-week double-blind, active …

Products of the prostaglandin H synthase (PGHS) metabolic pathway are thought to play a
role in the pathogenesis of asthma. We determined the level of expression of the constitutive (…

Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) has
been investigated in the ferret. The PDE IV inhibitors studied were: RS14203, R-rolipram and …

This review describes methodologies used to study experimental myocardial ischemic and
reperfusion injury. Myocardial reperfusion injury may be manifest as myocardial stunning, …