Ginsenosides: are any of them candidates for drugs acting on the central nervous system?

SY Nah, DH Kim, H Rhim - CNS drug reviews, 2007 - Wiley Online Library
The last two decades have shown a marked expansion in the number of publications regarding
the effects of Panax ginseng. Ginsenosides, which are unique saponins isolated from …

[HTML][HTML] Panax ginseng as an adjuvant treatment for Alzheimer's disease

…, SW Jung, SY Kim, IH Cho, HC Kim, H Rhim… - Journal of ginseng …, 2018 - Elsevier
Longevity in medicine can be defined as a long life without mental or physical deficits. This
can be prevented by Alzheimer's disease (AD). Current conventional AD treatments only …

Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases

…, ANM Mamum-Or-Rashid, MG Pang, H Rhim - … Science and Pollution …, 2020 - Springer
Neurodegenerative disorders are typically sporadic in nature in addition to usually influenced
through an extensive range of environmental factors, lifestyle, and genetic elements. …

Role of tumor necrosis factor-α in neuronal and glial apoptosis after spinal cord injury

YB Lee, TY Yune, SY Baik, YH Shin, S Du, H Rhim… - Experimental …, 2000 - Elsevier
We investigated the role of tumor necrosis factor (TNF)-α in the onset of neuronal and glial
apoptosis after traumatic spinal cord crush injury in rats. A few TUNEL-positive cells were first …

Increased Production of Tumor Necrosis Factor-α Induces Apoptosis after Traumatic Spinal Cord Injury in Rats

…, SJ Kim, YB Lee, SW Shin, H Rhim… - Journal of …, 2003 - liebertpub.com
We showed previously that, after spinal cord injury (SCI), tumor necrosis factor-α (TNF-α)
may serve as an external signal, initiating apoptosis in neurons and oligodendrocytes. To …

[HTML][HTML] The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn

…, E Kostenis, JI Kim, JY Seong, JH Baik, H Rhim - Journal of Biological …, 2007 - ASBMB
The human 5-HT 6 receptor (5-HT 6 R) is one of the latest cloned receptors among the
known 5-HT receptors. Its abundant distribution in the limbic region, which participates in the …

[PDF][PDF] Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2

D Jeon, YM Yang, MJ Jeong, KD Philipson, H Rhim… - Neuron, 2003 - cell.com
The plasma membrane Na + /Ca 2+ exchanger (NCX) plays a role in regulation of intracellular
Ca 2+ concentration via the forward mode (Ca 2+ efflux) or the reverse mode (Ca 2+ influx…

[HTML][HTML] Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92

…, H Choe, JY Lee, JI Kim, S Kim, H Rhim… - Journal of Biological …, 2008 - ASBMB
A series of small compounds acting at the orphan G protein-coupled receptor GPR92 were
screened using a signaling pathway-specific reporter assay system. Lipid-derived molecules …

FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells

KS Park, I Jo, Y Pak, SW Bae, H Rhim, SH Suh, S Park… - Pflügers Archiv, 2002 - Springer
We investigated the effects of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP),
a protonophore and uncoupler of mitochondrial oxidative phosphorylation in mitochondria, …

[HTML][HTML] Dyrk1A phosphorylates α-synuclein and enhances intracellular inclusion formation

EJ Kim, JY Sung, HJ Lee, H Rhim, M Hasegawa… - Journal of biological …, 2006 - ASBMB
Lewy bodies (LBs) are pathological hallmarks of Parkinson disease (PD) but also occur in
Alzheimer disease (AD) and dementia of LBs. α-Synuclein, the major component of LBs, is …