Inhibitors of IκB kinase (IKK) have long been sought as specific regulators of NF-κB. A
screening effort of the endogenous IKK complex allowed us to identify 5-bromo-6-methoxy-β-…

Targeted therapies that suppress B cell receptor (BCR) signaling have emerged as
promising agents in autoimmune disease and B cell malignancies. Bruton’s tyrosine kinase (Btk) …

Efforts at elimination of scourges, such as malaria, are limited by the logistic challenges of
reaching large rural populations and ensuring patient adherence to adequate pharmacologic …

The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence.
Long-acting enteral systems that can ease the burden of daily adherence have not yet …

Abstract Systems capable of residing for prolonged periods of time in the gastric cavity have
transformed our ability to diagnose and treat patients. Gastric resident systems for drug …

Asymmetric microbial reduction of a series of 2, 2-disubstituted 1, 3-cycloalkanediones with
bakers’ yeast was examined as an example of an enzyme-catalyzed distinction of a …

PI3Kα has been identified as an oncogene in human tumors. By use of rational drug design,
a targeted covalent inhibitor 3 (CNX-1351) was created that potently and specifically inhibits …

We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We
investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering …

Multigram drug depot systems for extended drug release could transform our capacity to
effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires …

Aggressive neurosurgical resection to achieve sustained local control is essential for
prolonging survival in patients with lower-grade glioma. However, progression in many of these …