User profiles for Hong-Gang Wang

Hong-Gang Wang

Professor of Pediatrics, Penn State College of Medicine
Verified email at psu.edu
Cited by 48227

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

T Miyashita, S Krajewski, M Krajewska, HG Wang… - Oncogene, 1994 - europepmc.org
The p53 tumor suppressor gene product can induce apoptotic cell death through an unknown
mechanism. Here we demonstrate that a temperature-sensitive p53 induces temperature-…

Ordering the cytochrome c–initiated caspase cascade: hierarchical activation of caspases-2,-3,-6,-7,-8, and-10 in a caspase-9–dependent manner

…, CA Casiano, DD Newmeyer, HG Wang… - The Journal of cell …, 1999 - rupress.org
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important
step in apoptosis. In the cytosol, cytochrome c binds to the CED-4 homologue, Apaf-1, …

The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins

…, H Saiga, M Satake, A Terry, L Yamada, HG Wang… - Science, 2002 - science.org
The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly
550 million years ago. The modern ascidian tadpole represents a plausible approximation to …

Ca2+-Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

HG Wang, N Pathan, IM Ethell, S Krajewski… - Science, 1999 - science.org
The Ca 2+ -activated protein phosphatase calcineurin induces apoptosis, but the mechanism
is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of …

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

…, JU Jung, JQ Cheng, JJ Mul, WJ Pledger, HG Wang - Nature cell …, 2007 - nature.com
Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential
for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how …

[HTML][HTML] Bcl-2 targets the protein kinase Raf-1 to mitochondria

HG Wang, UR Rapp, JC Reed - Cell, 1996 - cell.com
A green fluorescent protein (GFP)–Raf-1 fusion protein was used to show that Bcl-2 can
target this kinase to mitochondria. Active Raf-1 fused with targeting sequences from an outer …

[HTML][HTML] CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

H Yamaguchi, HG Wang - Journal of Biological Chemistry, 2004 - ASBMB
It has been shown that excess stress to the endoplasmic reticulum (ER) triggers apoptosis,
but the mechanisms underlying these processes remain unclear. We and others have …

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

…, A Shabaik, T Miyashita, HG Wang… - The American journal …, 1994 - ncbi.nlm.nih.gov
The protein encoded by the bcl-2 gene is a regulator of programmed cell death and apoptosis.
The cell survival-promoting activity of this protein is opposed by Bax, a homologous …

Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses

…, S Takayama, S Krajewski, HG Wang… - Blood, The Journal …, 1998 - ashpublications.org
B-cell chronic lymphocytic leukemia (B-CLL) represents a neoplastic disorder caused primarily
by defective programmed cell death (PCD), as opposed to increased cell proliferation. …

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

…, E Golemis, L Fong, HG Wang - Proceedings of the …, 1994 - National Acad Sciences
Interactions of the Bcl-2 protein with itself and other members of the Bcl-2 family, including
Bcl-XL, Bcl-XS, Mcl-1, and Bax, were explored with a yeast two-hybrid system. Fusion proteins …