User profiles for Hong-Gang Wang
Hong-Gang WangProfessor of Pediatrics, Penn State College of Medicine Verified email at psu.edu Cited by 48227 |
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
T Miyashita, S Krajewski, M Krajewska, HG Wang… - Oncogene, 1994 - europepmc.org
The p53 tumor suppressor gene product can induce apoptotic cell death through an unknown
mechanism. Here we demonstrate that a temperature-sensitive p53 induces temperature-…
mechanism. Here we demonstrate that a temperature-sensitive p53 induces temperature-…
Ordering the cytochrome c–initiated caspase cascade: hierarchical activation of caspases-2,-3,-6,-7,-8, and-10 in a caspase-9–dependent manner
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important
step in apoptosis. In the cytosol, cytochrome c binds to the CED-4 homologue, Apaf-1, …
step in apoptosis. In the cytosol, cytochrome c binds to the CED-4 homologue, Apaf-1, …
The Draft Genome of Ciona intestinalis: Insights into Chordate and Vertebrate Origins
The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly
550 million years ago. The modern ascidian tadpole represents a plausible approximation to …
550 million years ago. The modern ascidian tadpole represents a plausible approximation to …
Ca2+-Induced Apoptosis Through Calcineurin Dephosphorylation of BAD
The Ca 2+ -activated protein phosphatase calcineurin induces apoptosis, but the mechanism
is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of …
is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of …
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential
for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how …
for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how …
[HTML][HTML] Bcl-2 targets the protein kinase Raf-1 to mitochondria
HG Wang, UR Rapp, JC Reed - Cell, 1996 - cell.com
A green fluorescent protein (GFP)–Raf-1 fusion protein was used to show that Bcl-2 can
target this kinase to mitochondria. Active Raf-1 fused with targeting sequences from an outer …
target this kinase to mitochondria. Active Raf-1 fused with targeting sequences from an outer …
[HTML][HTML] CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
H Yamaguchi, HG Wang - Journal of Biological Chemistry, 2004 - ASBMB
It has been shown that excess stress to the endoplasmic reticulum (ER) triggers apoptosis,
but the mechanisms underlying these processes remain unclear. We and others have …
but the mechanisms underlying these processes remain unclear. We and others have …
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.
…, A Shabaik, T Miyashita, HG Wang… - The American journal …, 1994 - ncbi.nlm.nih.gov
The protein encoded by the bcl-2 gene is a regulator of programmed cell death and apoptosis.
The cell survival-promoting activity of this protein is opposed by Bax, a homologous …
The cell survival-promoting activity of this protein is opposed by Bax, a homologous …
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses
…, S Takayama, S Krajewski, HG Wang… - Blood, The Journal …, 1998 - ashpublications.org
B-cell chronic lymphocytic leukemia (B-CLL) represents a neoplastic disorder caused primarily
by defective programmed cell death (PCD), as opposed to increased cell proliferation. …
by defective programmed cell death (PCD), as opposed to increased cell proliferation. …
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.
Interactions of the Bcl-2 protein with itself and other members of the Bcl-2 family, including
Bcl-XL, Bcl-XS, Mcl-1, and Bax, were explored with a yeast two-hybrid system. Fusion proteins …
Bcl-XL, Bcl-XS, Mcl-1, and Bax, were explored with a yeast two-hybrid system. Fusion proteins …