Inhibitory profile of SEA0400 [2-[4-[(2, 5-difluorophenyl) methoxy] phenoxy]-5-ethoxyaniline] assessed on the cardiac Na+-Ca2+ exchanger, NCX1. 1

C Lee, NS Visen, NS Dhalla, HD Le, M Isaac… - … of Pharmacology and …, 2004 - ASPET
SEA0400 (2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline) has recently been
described as a potent and selective inhibitor of Na + -Ca 2+ exchange in cardiac, neuronal, …

[HTML][HTML] The molecular determinants of ionic regulatory differences between brain and kidney Na+/Ca2+ exchanger (NCX1) isoforms

J Dunn, CL Elias, HD Le, A Omelchenko… - Journal of Biological …, 2002 - ASBMB
The Na + /Ca 2+ exchanger gene NCX1 undergoes alternative splicing leading to several
isoforms that differ in a small portion of the large cytoplasmic loop. This loop is involved in …

[HTML][HTML] Crystal structures of progressive Ca2+ binding states of the Ca2+ sensor Ca2+ binding domain 1 (CBD1) from the CALX Na+/Ca2+ exchanger reveal …

M Wu, HD Le, M Wang, V Yurkov, A Omelchenko… - Journal of Biological …, 2010 - ASBMB
Na + /Ca 2+ exchangers (NCX) constitute a major Ca 2+ export system that facilitates the re-establishment
of cytosolic Ca 2+ levels in many tissues. Ca 2+ interactions at its Ca 2+ …

Insulin resistance in gestational diabetes mellitus and its association with anthropometric fetal indices

T Dinh Le, T Minh Bui, T Hien Vu… - Clinical Medicine …, 2022 - journals.sagepub.com
Background: In pregnant women with gestational diabetes mellitus (GDM), insulin resistance
(IR) increases the risk of developing manifest type 2 diabetes mellitus and is associated …

Effects of SEA0400 on mutant NCX1. 1 Na+-Ca2+ exchangers with altered ionic regulation

R Bouchard, A Omelchenko, HD Le, P Choptiany… - Molecular …, 2004 - ASPET
SEA0400 (SEA) blocks cardiac and neuronal Na + -Ca 2+ exchange with the highest affinity
of any known inhibitor, yet very little is known about its molecular mechanism of action. …

Low-grade inflammation in gestational diabetes mellitus and its correlation with maternal insulin resistance and fetal growth indices

…, HT Dinh, T Viet Tran, T Dinh Le… - … Journal of General …, 2023 - Taylor & Francis
Introduction Chronic low-grade inflammation (LGI) plays a role in the pathogenesis of gestational
diabetes mellitus (GDM). LGI, on the one hand, promotes insulin resistance and at the …

Inhibition of canine (NCX1. 1) and Drosophila (CALX1. 1) Na+-Ca2+ exchangers by 7-chloro-3, 5-dihydro-5-phenyl-1H-4, 1-benzothiazepine-2-one (CGP-37157)

A Omelchenko, R Bouchard, HD Le, P Choptiany… - … of Pharmacology and …, 2003 - ASPET
The electrophysiological effects of the benzothiazepine 7-chloro-3,5-dihydro-5-phenyl-1H-4,1-benzothiazepine-2-one
(CGP-37157) (CGP) were investigated on the canine (NCX1.1) …

Determinants of cardiac Na+/Ca2+exchanger temperature dependence: NH2-terminal transmembrane segments

C Marshall, C Elias, XH Xue, HD Le… - … of Physiology-Cell …, 2002 - journals.physiology.org
The cardiac Na + /Ca 2+ exchanger (NCX) in trout exhibits profoundly lower temperature
sensitivity in comparison to the mammalian NCX. In this study, we attempt to characterize the …

Characterization of zebrafish (Danio rerio) NCX4: a novel NCX with distinct electrophysiological properties

C On, CR Marshall, SF Perry, HD Le… - … of Physiology-Cell …, 2009 - journals.physiology.org
Members of the Na + /Ca 2+ exchanger (NCX) family are important regulators of cytosolic
Ca 2+ in myriad tissues and are highly conserved across a wide range of species. Three …

[HTML][HTML] cDNA cloning and expression of the cardiac Na+/Ca2+ exchanger from Mozambique tilapia (Oreochromis mossambicus) reveal a teleost membrane …

CR Marshall, TC Pan, HD Le, A Omelchenko… - Journal of Biological …, 2005 - ASBMB
The complete cDNA sequence of the tilapia cardiac Na + /Ca 2+ exchanger (NCX-TL1.0)
was determined. The 3.1-kb transcript encodes a protein 957 amino acids in length, with a …