Substantial evidence suggests that chromosomal abnormalities contribute to the risk of
autism. The duplication of human chromosome 15q11-13 is known to be the most frequent …

An object location test (OLT) has been developed to test spatial memory in rats. The test is
based on the spontaneous tendency of rodents, previously exposed to two identical objects, …

Introduction. Classical opioid receptors (µ, δ, and κ) have important physiological and
pharmacological roles, especially in pain regulation. A fourth opioid receptor, opioid receptor-like …

We identified 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide
27 as a potent mGluR1 antagonist. The compound possessed excellent subtype …

Novel isoxazolopyridone derivatives that are metabotropic glutamate receptor (mGluR) 7
antagonists were discovered and pharmacologically characterized. 5-Methyl-3,6-…

1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
(J-113397) was found to be the first potent nonpeptidyl ORL1 receptor …

The effects of persimmon tannin on pathophysiological changes in stroke-prone
spontaneously hypertensive rats (SHRSP) were investigated. When the persimmon tannin was …

The functional roles of metabotropic glutamate receptor (mGluR) 1 in integrative brain functions
were investigated using a potent and selective mGluR1 allosteric antagonist, FTIDC [4-[1-…

We describe here the discovery and biological profile of a series of isoindolinone derivatives
as developed mGluR1 antagonists. Our combined strategy of rapid parallel synthesis and …

In this study, we determined whether either N-methyl-D-aspartate (NMDA) receptors or non-NMDA
receptors in the nucleus tractus solitarii (NTS) participate in the baroreceptor reflex in …