A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
S Nakagawa, MA Deli, H Kawaguchi… - Neurochemistry …, 2009 - Elsevier
Blood–brain barrier (BBB) characteristics are induced and maintained by cross-talk between
brain microvessel endothelial cells and neighbouring elements of the neurovascular unit. …
brain microvessel endothelial cells and neighbouring elements of the neurovascular unit. …
[HTML][HTML] Max is a repressor of germ cell-related gene expression in mouse embryonic stem cells
…, D Okamura, Y Tokitake, M Ikeda, H Kawaguchi… - Nature …, 2013 - nature.com
Embryonic stem cells and primordial germ cells (PGCs) express many pluripotency-associated
genes, but embryonic stem cells do not normally undergo conversion into primordial …
genes, but embryonic stem cells do not normally undergo conversion into primordial …
[HTML][HTML] Highly effective recombinant format of a humanized IgG-like bispecific antibody for cancer immunotherapy with retargeting of lymphocytes to tumor cells
R Asano, Y Watanabe, H Kawaguchi… - Journal of biological …, 2007 - ASBMB
We previously reported the marked in vitro and in vivo antitumor activity of hEx3, a humanized
diabody (small recombinant bispecific antibody) with epidermal growth factor receptor (…
diabody (small recombinant bispecific antibody) with epidermal growth factor receptor (…
Initiation of meiosis and sporulation in Saccharomyces cerevisiae requires a novel protein kinase homologue
M Yoshida, H Kawaguchi, Y Sakata… - Molecular and General …, 1990 - Springer
SME1 was cloned due to its high copy number effect: it enabled MATα/MATα diploid cells to
undergo meiosis and sporulation in a vegetative medium. Disruption of SME1 resulted in a …
undergo meiosis and sporulation in a vegetative medium. Disruption of SME1 resulted in a …
Construction and humanization of a functional bispecific EGFR× CD16 diabody using a refolding system
R Asano, M Nakayama, H Kawaguchi… - The FEBS …, 2012 - Wiley Online Library
We previously reported the construction and activity of a humanized, bispecific diabody (hEx3)
that recruited T cells towards an epidermal growth factor receptor (EGFR) positive tumor. …
that recruited T cells towards an epidermal growth factor receptor (EGFR) positive tumor. …
Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting of lymphocytes to tumor cells
R Asano, H Kawaguchi, Y Watanabe… - Journal of …, 2008 - journals.lww.com
Recently, recombinant antibodies have been dissected into antigen-binding regions and
rebuilt into multivalent high-avidity formats. These new structural designs are expected to …
rebuilt into multivalent high-avidity formats. These new structural designs are expected to …
[HTML][HTML] Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody
R Asano, K Ikoma, Y Sone, H Kawaguchi, S Taki… - Journal of biological …, 2010 - ASBMB
We previously reported the utility for cancer immunotherapy of a humanized bispecific diabody
(hEx3) that targets epidermal growth factor receptor and CD3. Here, we used dynamic …
(hEx3) that targets epidermal growth factor receptor and CD3. Here, we used dynamic …
Application of the Fc fusion format to generate tag‐free bi‐specific diabodies
R Asano, K Ikoma, H Kawaguchi, Y Ishiyama… - The FEBS …, 2010 - Wiley Online Library
We previously reported the use of a humanized bi‐specific diabody that targets epidermal
growth factor receptor and CD3 (hEx3‐Db) for cancer immunotherapy. Bacterial expression …
growth factor receptor and CD3 (hEx3‐Db) for cancer immunotherapy. Bacterial expression …
Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in …
S Hayashi, H Kawaguchi, T Watanabe, I Miyawaki… - Xenobiotica, 2023 - Taylor & Francis
Full article: Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and
prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in …
prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in …
Micro fluorescent analysis system integrating GaN-light-emitting-diode on a silicon platform
H Nakazato, H Kawaguchi, A Iwabuchi, K Hane - Lab on a Chip, 2012 - pubs.rsc.org
A micro fluorescent analysis system is proposed using silicon micromachining. GaN blue
light-emitting diode (LED) monolithically integrated on a silicon substrate is used as a light …
light-emitting diode (LED) monolithically integrated on a silicon substrate is used as a light …