It is important to predict the potential of cosmetic ingredients to cause skin sensitization, and
in accordance with the European Union cosmetic directive for the replacement of animal …

As one of the Na + -dependent transporters responsible for the hepatic uptake of ligands,
sodium taurocholate (TC) co-transporting polypeptide (NTCP) has been cloned from rat liver …

The sensitizing potential of chemicals is usually identified and characterized using in vivo
methods such as the murine local lymph node assay (LLNA). Due to regulatory constraints and …

The main purpose of the present study was to establish a non-animal photosafety assessment
approach for cosmetics using in vitro photochemical and photobiochemical screening …

The mechanism for hepatic uptake of temocaprilat, an angiotensin-converting enzyme inhibitor
that is predominantly excreted into bile was studied using isolated rat hepatocytes and …

Purpose. The biliary excreted amount of indomethacin and itsglucuronide is related to the
intestinal toxicity of this drug. In the presentstudy, we investigated the hepatobiliary transport of …

In order to develop in vitro risk assessment systems for skin sensitization, it is important to
predict a threshold from the murine local lymph node assay (LLNA). We first confirmed that the …

Drug-induced liver injury (DILI) can cause hepatic failure and result in drug withdrawal from
the market. It has host-related and compound-dependent mechanisms. Preclinical prediction …

Use of laboratory animals for systemic toxicity testing is subject to strong ethical and
regulatory constraints, but few alternatives are yet available. One possible approach to predict …

Organic anion transporting polypeptide (oatp1) has been cloned from rat liver as one of the
transporters responsible for the hepatic uptake of ligands, and its substrate specificity has …