Primary carnitine deficiency, because of a defect of the tissue plasma membrane carnitine
transporters, causes critical symptoms. However, the transporter has not been molecularly …

Primary systemic carnitine deficiency (SCD; OMIM 212140) is an autosomal recessive disorder
characterized by progressive cardiomyopathy, skeletal myopathy, hypoglycaemia and …

Abscisic acid (ABA) is one of the most important phytohormones involved in abiotic stress
responses, seed maturation, germination, and senescence. ABA is predominantly produced in …

cDNA for a novel proton/organic cation transporter, OCTN1, was cloned from human fetal liver
and its transport activity was investigated. OCTN1 encodes a 551‐amino acid protein with …

In the present study, functional characteristics of organic cation transporter (OCTN)1, which
was cloned as the pH-dependent tetraethylammonium (TEA) transporter when expressed in …

Carnitine deficiency, either primary or drug-induced, causes critical symptoms and is thought
to involve alteration of active transport of carnitine across the plasma membrane of tissues …

Gefitinib (Iressa™) is a selective epidermal growth factor receptor tyrosine kinase inhibitor
and is used for the treatment of lung cancer. Recently, we discovered that it inhibits the breast …

Hypertension in patients with chronic kidney disease (CKD) strongly associates with
cardiovascular events. Among patients with CKD, reducing the accumulation of uremic toxins may …

Organic anions are secreted into urine via organic anion transporters across the renal
basolateral and apical membranes. However, no apical membrane transporter for organic anions …

Purpose To examine the mechanisms of the alteration of serum uric acid level by angiotensin
II receptor blockers (ARBs), the effects of ARBs on renal uric acid transporters, including …