User profiles for Hideki Nishitoh

Hideki Nishitoh

Department of Medical Sciences, University of Miyazaki
Verified email at med.miyazaki-u.ac.jp
Cited by 15765

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

H Nishitoh, A Matsuzawa, K Tobiume… - Genes & …, 2002 - genesdev.cshlp.org
Expansion of CAG trinucleotide repeats that encode polyglutamine is the underlying cause
of at least nine inherited human neurodegenerative disorders, including Huntington's …

[HTML][HTML] Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

M Saitoh, H Nishitoh, M Fujii, K Takeda… - The EMBO …, 1998 - embopress.org
Apoptosis signal‐regulating kinase (ASK) 1 was recently identified as a mitogen‐activated
protein (MAP) kinase kinase kinase which activates the c‐Jun N‐terminal kinase (JNK) and …

[HTML][HTML] ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

K Tobiume, A Matsuzawa, T Takahashi, H Nishitoh… - EMBO …, 2001 - embopress.org
Apoptosis signal‐regulating kinase (ASK) 1 is activated in response to various cytotoxic
stresses including TNF, Fas and reactive oxygen species (ROS) such as H 2 O 2, and activates c…

[PDF][PDF] ASK1 is essential for JNK/SAPK activation by TRAF2

H Nishitoh, M Saitoh, Y Mochida, K Takeda, H Nakano… - Molecular cell, 1998 - cell.com
Tumor necrosis factor (TNF)-induced activation of the c-jun N-terminal kinase (JNK, also
known as SAPK; stress-activated protein kinase) requires TNF receptor-associated factor 2 (…

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

…, K Saegusa, T Noguchi, C Sadamitsu, H Nishitoh… - Nature …, 2005 - nature.com
Apoptosis signal–regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated
protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases. Here …

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

HY Chang, H Nishitoh, X Yang, H Ichijo, D Baltimore - Science, 1998 - science.org
The Fas death receptor can activate the Jun NH 2 -terminal kinase (JNK) pathway through the
receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1…

Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor …

H Liu, H Nishitoh, H Ichijo… - Molecular and cellular …, 2000 - Am Soc Microbiol
The stress-activated protein kinases (SAPKs, also called c-Jun NH 2-terminal kinases) and
the p38s, two mitogen-activated protein kinase (MAPK) subgroups activated by cytokines of …

ALS-linked mutant SOD1 induces ER stress-and ASK1-dependent motor neuron death by targeting Derlin-1

H Nishitoh, H Kadowaki, A Nagai… - Genes & …, 2008 - genesdev.cshlp.org
Mutation in Cu/Zn-superoxide dismutase (SOD1) is a cause of familial amyotrophic lateral
sclerosis (ALS). Mutant SOD1 protein (SOD1 mut ) induces motor neuron death, although the …

CHOP is a multifunctional transcription factor in the ER stress response

H Nishitoh - The Journal of Biochemistry, 2012 - academic.oup.com
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) induces ER stress.
To restore ER homeostasis, cells possess a highly specific ER quality-control system called …

[HTML][HTML] Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5

H Nishitoh, H Ichijo, M Kimura, T Matsumoto… - Journal of biological …, 1996 - ASBMB
Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein (BMP)
family, which plays an important role in bone development in vivo. Mutations in the GDF-5 …