Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro

N Hattori, H Nomoto, H Fukumitsu, S Mishima… - Biomedical …, 2007 - jstage.jst.go.jp
Neural stem/progenitor cells (NSCs) proliferate vigorously as neurospheres in medium
containing basic fibroblast growth factor (FGF-2), but start differentiating into neurons, astrocytes …

Brain-derived neurotrophic factor participates in determination of neuronal laminar fate in the developing mouse cerebral cortex

H Fukumitsu, M Ohtsuka, R Murai… - Journal of …, 2006 - Soc Neuroscience
Lamina formation in the developing cerebral cortex requires precisely regulated generation
and migration of the cortical progenitor cells. To test the possible involvement of brain-…

Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse …

…, T Nakamura, Y Ogawa, H Fukumitsu… - Bioscience …, 2005 - jstage.jst.go.jp
Royal jelly (RJ) is known to have a variety of biological activities toward various types of
cells and tissues of animal models, but nothing is known about its effect on brain functions. …

Transforming growth factor‐β1 enhances expression of brain‐derived neurotrophic factor and its receptor, TrkB, in neurons cultured from rat cerebral cortex

…, H Kataoka, A Nitta, H Fukumitsu… - Journal of …, 2001 - Wiley Online Library
The effects of transforming growth factor (TGF)‐β1 on expression of brain‐derived neurotrophic
factor (BDNF) and its high‐affinity receptor, TrkB, in neurons cultured from the cerebral …

Inflammation-induced GDNF improves locomotor function after spinal cord injury

M Hashimoto, A Nitta, H Fukumitsu, H Nomoto… - …, 2005 - journals.lww.com
Activation of microglia/macrophages after injury occurs limitedly in the CNS, which finding
may explain unsuccessful axonal regeneration. Therefore, the relationship between …

Prenatal immune challenge compromises the normal course of neurogenesis during development of the mouse cerebral cortex

H Soumiya, H Fukumitsu… - Journal of neuroscience …, 2011 - Wiley Online Library
Maternal infection during pregnancy is an environmental risk factor for the development of
severe brain disorders in offspring, including schizophrenia and autism. However, little is …

[HTML][HTML] Antidepressant-like activity of 10-hydroxy-trans-2-decenoic acid, a unique unsaturated fatty acid of royal jelly, in stress-inducible depression-like mouse model

S Ito, Y Nitta, H Fukumitsu, H Soumiya… - Evidence-Based …, 2012 - hindawi.com
Symptoms of depression and anxiety appeared in mice after they had been subjected to a
combination of forced swimming for 15 min followed by being kept in cages that were …

Royal jelly-induced neurite outgrowth from rat pheochromocytoma PC12 cells requires integrin signal independent of activation of extracellular signalregulated …

N Hattori, H Nomoto, H Fukumitsu, S Mishima… - Biomedical …, 2007 - jstage.jst.go.jp
We showed earlier that neurite outgrowth of rat pheochromocytoma PC12 cells was stimulated
by royal jelly extract (PERJ) or its unique component, AMP N1-oxide, via adenosine A2a …

Involvement of glial cell line‐derived neurotrophic factor in activation processes of rodent macrophages

M Hashimoto, A Nitta, H Fukumitsu… - Journal of …, 2005 - Wiley Online Library
The physiological roles of glial cell line‐derived neurotrophic factor (GDNF) expressed in
the microglia/macrophages of the injured spinal cord have not yet been clarified. mRNA …

Pyrroloquinoline quinone attenuates iNOS gene expression in the injured spinal cord

A Hirakawa, K Shimizu, H Fukumitsu… - … and biophysical research …, 2009 - Elsevier
Pyrroloquinoline quinone (PQQ) is a naturally occurring redox cofactor that acts as an essential
nutrient, antioxidant, and redox modulator. PQQ has been demonstrated to oxidize the …