Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes

…, HW Morselt, HE Moorlag, HI Bakker… - American Journal …, 2008 - journals.physiology.org
E-selectin-directed targeted drug delivery was analyzed in anti-glomerular basement
membrane glomerulonephritis. Liposomes conjugated with anti-E-selectin antibodies (Ab Esel …

Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo

L Beljaars, BWA van der Strate, HI Bakker… - Antiviral research, 2004 - Elsevier
Lactoferrin is an antimicrobial agent, that, amongst other viruses, inhibits cytomegalovirus (CMV).
In this study, we addressed the mechanism(s) by which lactoferrin interacts with CMV …

Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium

SA Asgeirsdottir, JAAM Kamps, HI Bakker… - Molecular …, 2007 - ASPET
Glomerulonephritis represents a group of renal diseases with glomerular inflammation as a
common pathologic finding. Because of the underlying immunologic character of these …

The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo

R Greupink, HI Bakker, W Bouma, C Reker-Smit… - … of Pharmacology and …, 2006 - ASPET
Hepatic stellate cell (HSC) proliferation is a key event in liver fibrosis; therefore, pharmacological
intervention with antiproliferative drugs may result in antifibrotic effects. In this article, …

Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell

R Greupink, HI Bakker, C Reker-Smit, RJ Kok… - Journal of …, 2005 - Elsevier
BACKGROUND/AIMS: Hepatic stellate cell (HSC) activation and proliferation are key events
in the pathology of liver fibrosis. Inhibiting these parameters, therefore, is a relevant option …

Mannose-6-phosphate/insulin-like growth factor-II receptors may represent a target for the selective delivery of mycophenolic acid to fibrogenic cells

R Greupink, HI Bakker, H van Goor, MH de Borst… - Pharmaceutical …, 2006 - Springer
Purpose The insulin-like growth factor axis plays an important role in fibrogenesis. However,
little is known about mannose-6-phosphate/Insulin-like growth factor-II receptor (M6P/IGF-…

Design and fungicidal activity of mucoadhesive lactoferrin tablets for the treatment of oropharyngeal candidosis

ME Kuipers, J Heegsma, HI Bakker, DKF Meijer… - Drug Delivery, 2002 - Taylor & Francis
Lactoferrin (Lf) is a potential drug candidate for the treatment of oropharyngeal Candida
infections. However, for an effective therapeutic treatment an appropriate dosage form is …

Synergy of bovine lactoferrin with the anti-cytomegalovirus drug cidofovir in vitro

BWA van der Strate, FM De Boer, HI Bakker… - Antiviral research, 2003 - Elsevier
Human cytomegalovirus (HCMV) causes severe morbidity and mortality in immunocompromised
patients. Treatment of HCMV infections with conventional antiviral drugs like ganciclovir …

The antiviral protein human lactoferrin is distributed in the body to cytomegalovirus (CMV) infection-prone cells and tissues

L Beljaars, HI Bakker, BWA van der Strate, C Smit… - Pharmaceutical …, 2002 - Springer
Purpose. Lactoferrin has anti-Cytomegalovirus (CMV) and -HIV properties in vitro. However,
the pharmacokinetic behavior of the 80-kD protein has not been well defined. We, therefore, …

A phase I/IIa study with succinylated human serum albumin (Suc-HSA), a candidate HIV-1 fusion inhibitor

…, DKF Meijer, J Over, JMA Lange, JH Proost, HI Bakker… - 2007 - journals.sagepub.com
Background Succinylated human serum albumin (Suc-HAS) is a negatively charged neo-glycoprotein
that binds to the positively charged V3–loop of HIV-1 gp120, acting as HIV-1-…