Hearts from α1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted
heterotopically into baboons using an anti-CD154 monoclonal antibody–based regimen. The …

The use of animal organs could potentially alleviate the critical worldwide shortage of donor
organs for clinical transplantation. Because of the strong immune response to xenografts, …

Background. This report describes the preclinical pharmacological profile of the new rapamycin
analog, SDZ RAD, ie, 40-O-(2-hydroxyethyl)-rapamycin. Methods. The pharmacological …

Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of
diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of …

Diabetes is induced in mice by using streptozotocin (STZ), a compound that has a preferential
toxicity toward pancreatic β cells. We evaluated nude male mice from various sources for …

The presence of immunologic markers for neurofilaments, neuropeptides of sensory nerve
fibers (Calcitonin gene-related peptide and substance P), for noradrenergic innervation (…

Background. SDZ RAD is a new rapamycin analog with potent immunosuppressive activity.
Compounds of the rapamycin class differ in their mode of action from cyclosporine, thus …

Background. The recent generation of α1, 3-galactosyltransferase gene-knockout (GalT-KO)
pigs has allowed investigation of the survival of GalT-KO pig organs in nonhuman primates. …

Here we report the identification of inbred miniature swine that failed to produce human-tropic
replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro …

Heterotopic cardiac xenotransplantation from α1,3-galactosyltransferase gene-knockout (GalT-KO)
swine to baboons was performed to characterize immunological reaction to the …