Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases
CC Felder, PJ Goldsmith, K Jackson, HE Sanger… - …, 2018 - Elsevier
The cholinergic signalling system has been an attractive pathway to seek targets for modulation
of arousal, cognition, and attention which are compromised in neurodegenerative and …
of arousal, cognition, and attention which are compromised in neurodegenerative and …
[HTML][HTML] M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
SJ Bradley, JM Bourgognon, HE Sanger… - The Journal of …, 2017 - Am Soc Clin Investig
The current frontline symptomatic treatment for Alzheimer’s disease (AD) is whole-body
upregulation of cholinergic transmission via inhibition of acetylcholinesterase. This approach …
upregulation of cholinergic transmission via inhibition of acetylcholinesterase. This approach …
The atypical 'hippocampal'glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric …
…, FC Shenton, HE Sanger… - Experimental …, 2024 - Wiley Online Library
A metabotropic glutamate receptor coupled to phospholipase D (PLD‐mGluR) was discovered
in the hippocampus over three decades ago. Its pharmacology and direct linkage to PLD …
in the hippocampus over three decades ago. Its pharmacology and direct linkage to PLD …
Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes
…, AJ Mogg, KJ Thompson, L Dwomoh, HE Sanger… - Molecular …, 2018 - ASPET
The realization of the therapeutic potential of targeting the M 1 muscarinic acetylcholine receptor
(mAChR) for the treatment of cognitive decline in Alzheimer’s disease has prompted the …
(mAChR) for the treatment of cognitive decline in Alzheimer’s disease has prompted the …
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist
…, X Li, LM Broad, F Pasqui, SM Fitzjohn, HE Sanger… - …, 2017 - Elsevier
Metabotropic glutamate 2/3 (mGlu 2/3 ) receptors are of considerable interest owing to their
role in modulating glutamate transmission via presynaptic, postsynaptic and glial …
role in modulating glutamate transmission via presynaptic, postsynaptic and glial …
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors
LM Broad, HE Sanger, AJ Mogg… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose We aimed to identify and develop novel, selective muscarinic M 1
receptor agonists as potential therapeutic agents for the symptomatic treatment of …
receptor agonists as potential therapeutic agents for the symptomatic treatment of …
In vitro pharmacological characterization and in vivo validation of LSN3172176 a novel M1 selective muscarinic receptor agonist tracer molecule for positron emission …
…, T Eessalu, M Johnson, R Wright, HE Sanger… - … of Pharmacology and …, 2018 - ASPET
In the search for improved symptomatic treatment options for neurodegenerative and
neuropsychiatric diseases, muscarinic acetylcholine M1 receptors (M1 mAChRs) have received …
neuropsychiatric diseases, muscarinic acetylcholine M1 receptors (M1 mAChRs) have received …
Ishimoto Shizue: The Margaret Sanger of Japan
EK Tipton - Women's History Review, 1997 - Taylor & Francis
… continued and grew throughout the following decades, ending only with Sanger’s death in
… strong influence from Sanger, but at the same time it was not a simple replication of Sanger’s …
… strong influence from Sanger, but at the same time it was not a simple replication of Sanger’s …
Modernism, Monsters, and Margaret Sanger
AA Wilson - MFS Modern Fiction Studies, 2013 - muse.jhu.edu
… By examining the depiction of the maternal body within the texts of Sanger, Vorse, and
Wellman, we see a side of aesthetic autonomy that is anything but autonomous: although artists …
Wellman, we see a side of aesthetic autonomy that is anything but autonomous: although artists …
[BOOK][B] Margaret Sanger: an autobiography
K Cullen-DuPont - 1999 - books.google.com
Thanks in large part to Margaret Sanger, many of the world's women live with a freedom …
The world Margaret Sanger's mother knew was a different one. As Margaret tells it in her …
The world Margaret Sanger's mother knew was a different one. As Margaret tells it in her …