Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning

MJ Frank, AA Moustafa, HM Haughey… - Proceedings of the …, 2007 - National Acad Sciences
What are the genetic and neural components that support adaptive learning from positive
and negative outcomes? Here, we show with genetic analyses that three independent …

“Spice” and “K2” herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans

EW Gunderson, HM Haughey… - … American journal on …, 2012 - Wiley Online Library
Cannabis, the most commonly used illicit substance, exerts its primary psychoactive effect
via delta‐9 tetrahydrocannabinol (Δ 9 ‐THC) agonism of cannabinoid receptor type 1 (CB1). …

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial

…, PEH Jackson, TD Bell, HM Haughey… - The lancet respiratory …, 2022 - thelancet.com
Background Baricitinib and dexamethasone have randomised trials supporting their use for
the treatment of patients with COVID-19. We assessed the combination of baricitinib plus …

Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes

HM Haughey, E Marshall, JP Schacht, A Louis… - …, 2008 - Wiley Online Library
Aim To examine whether withdrawal after abstinence and cue‐elicited craving were associated
with polymorphisms within two genes involved in regulating the endocannabinoid system…

A survey of synthetic cannabinoid consumption by current cannabis users

EW Gunderson, HM Haughey, N Ait-Daoud… - Substance …, 2014 - journals.sagepub.com
Background Despite growing concern about the increased rates of synthetic cannabinoid (SC)
use and their effects, only limited data are available that addresses these issues. This …

CHRNA4 and tobacco dependence: from gene regulation to treatment outcome

…, A Bryan, J McGeary, HM Haughey - Archives of general …, 2007 - jamanetwork.com
Context Given the probable importance of the α4 subunit of the neuronal nicotinic acetylcholine
receptor, the gene that codes for this subunit (CHRNA4) represents an excellent starting …

Renin-angiotensin system modulation with synthetic angiotensin (1-7) and angiotensin II type 1 receptor–biased ligand in adults with COVID-19: two randomized …

…, J Mason, PEH Jackson, RW Coleman, HM Haughey… - Jama, 2023 - jamanetwork.com
Importance Preclinical models suggest dysregulation of the renin-angiotensin system (RAS)
caused by SARS-CoV-2 infection may increase the relative activity of angiotensin II …

Differential effects of psychostimulants and related agents on dopaminergic and serotonergic transporter function

AE Fleckenstein, HM Haughey, RR Metzger… - European journal of …, 1999 - Elsevier
High-dose administrations of amphetamine, methamphetamine, cathinone, methcathinone
or methylenedioxymethamphetamine rapidly decrease dopamine and serotonin transporter …

Methamphetamine-induced rapid decrease in dopamine transporter function: role of dopamine and hyperthermia

RR Metzger, HM Haughey, DG Wilkins, JW Gibb… - … of Pharmacology and …, 2000 - ASPET
Single and multiple high-dose administrations of methamphetamine (METH) differentially
decrease dopamine (DA) transporter (DAT) function, as assessed by measuring [ 3 H]DA …

Safety and efficacy of dupilumab for the treatment of hospitalized patients with moderate to severe coronavirus disease 2019: a phase 2a trial

…, AN Donlan, JZ Ma, HM Haughey… - Open Forum …, 2022 - academic.oup.com
Background Based on studies implicating the type 2 cytokine interleukin 13 (IL-13) as a
potential contributor to critical coronavirus disease 2019 (COVID-19), this trial was designed as …