Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclase
U Schindler, H Strobel, K Schönafinger, W Linz… - Molecular …, 2006 - ASPET
The heme-enzyme soluble guanylyl cyclase (sGC) is an ubiquitous NO receptor, which
mediates NO downstream signaling by the generation of cGMP. We studied the mechanism of …
mediates NO downstream signaling by the generation of cGMP. We studied the mechanism of …
Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling
…, EI Closs, T Hübschle, C Mang, H Strobel… - … of Pharmacology and …, 2008 - ASPET
Many cardiovascular diseases are associated with reduced levels of bioactive nitric oxide (NO)
and an uncoupling of oxygen reduction from NO synthesis in endothelial NO synthase (…
and an uncoupling of oxygen reduction from NO synthesis in endothelial NO synthase (…
Inhibition of Neuronal Nitric Oxide Synthase by 4-Amino Pteridine Derivatives: Structure−Activity Relationship of Antagonists of (6R)-5,6,7,8-Tetrahydrobiopterin …
…, N Al-Masoudi, H Hofmann, H Strobel… - Journal of medicinal …, 1999 - ACS Publications
The family of nitric oxide synthases (NOS) catalyzes the conversion of l-arginine to l-citrulline
and nitric oxide (NO), an important cellular messenger molecule which has been implicated …
and nitric oxide (NO), an important cellular messenger molecule which has been implicated …
Release of nitric oxide from endothelial cells stimulated by YC‐1, an activator of soluble guanylyl cyclase
…, W Linz, K Schoenafinger, H Strobel… - British journal of …, 1999 - Wiley Online Library
In this study we examined the endothelium‐dependent effect of YC‐1–a benzyl indazole
derivative which directly activates soluble guanylyl cyclase (sGC)–on vascular relaxation and …
derivative which directly activates soluble guanylyl cyclase (sGC)–on vascular relaxation and …
Identification of potent and long-acting single-chain peptide mimetics of human relaxin-2 for cardiovascular diseases
…, A Raux, L Riva, P Janiak, H Strobel… - Journal of Medicinal …, 2021 - ACS Publications
The insulin-like peptide human relaxin-2 was identified as a hormone that, among other
biological functions, mediates the hemodynamic changes occurring during pregnancy. …
biological functions, mediates the hemodynamic changes occurring during pregnancy. …
Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo-and 4-amino-pteridine-based inhibitors
H Matter, P Kotsonis, O Klingler, H Strobel… - Journal of medicinal …, 2002 - ACS Publications
The family of homodimeric nitric oxide synthases (NOS I−III) catalyzes the generation of the
cellular messenger nitric oxide (NO) by oxidation of the substrate l-arginine. The rational …
cellular messenger nitric oxide (NO) by oxidation of the substrate l-arginine. The rational …
Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: Advantages in comparison with competitive inhibitors
…, G Harlow, A Hittinger, S Ruf, H Strobel… - Bioorganic & medicinal …, 2011 - Elsevier
A new series of IGF-1R inhibitors related to hydantoins were identified from a lead originating
from HTS. Their noncompetitive property as well as their slow binding characteristics …
from HTS. Their noncompetitive property as well as their slow binding characteristics …
[HTML][HTML] Structural basis for pterin antagonism in nitric-oxide synthase: Development of novel 4-oxo-pteridine antagonists of (6R)-5, 6, 7, 8-tetrahydrobiopterin
…, P Martásek, BSS Masters, H Strobel… - Journal of Biological …, 2001 - ASBMB
Pathological nitric oxide (NO) generation in sepsis, inflammation, and stroke may be
therapeutically controlled by inhibiting NO synthases (NOS). Here we targeted the (6R)-5,6,7,8-…
therapeutically controlled by inhibiting NO synthases (NOS). Here we targeted the (6R)-5,6,7,8-…
Darstellung und optische Eigenschaften endständig substituierter Polyene mit Androstan als Spacer
F Effenberger, H Strobel - Chemische Berichte, 1993 - Wiley Online Library
Synthesis and Optical Properties of Terminally Substituted Conjugated Polyenes with
Androstane as Spacer The conjugated polyenes 10, 11, 21, 22, and 26 with 9‐anthryl and 2‐…
Androstane as Spacer The conjugated polyenes 10, 11, 21, 22, and 26 with 9‐anthryl and 2‐…
[HTML][HTML] Role of the sGC activator ataciguat sodium (HMR1766) in cardiovascular disease
…, S Wassmann, A Schäfer, J Bauersachs, H Strobel… - BMC …, 2007 - Springer
Background Soluble guanylate cyclase (sGC), the key transducer of nitric oxide (NO)
signaling, exists in two redox forms: the NO sensitive ferrous heme iron (Fe (II)) form and a NO …
signaling, exists in two redox forms: the NO sensitive ferrous heme iron (Fe (II)) form and a NO …