Prodrugs are substances administered in an inactive form that is then metabolized in the
body in vivo into the active compound. The rationale behind administering prodrugs is to …

Nucleoside analogues are widely used for the treatment of antiviral infections and anticancer
chemotherapy. However, many nucleoside analogues suffer from poor oral bioavailability …

A series of nucleosides were synthesized in which the 4'-hydrogen was substituted with
either an azido or a methoxy group. The key steps in the syntheses of the 4'-azido analogues …

Carboxylic acids are often present as a functional group of effective medicines. They are
involved in specific charge-charge interactions and are thus often critical for the binding of …

The discovery of 4′-azidocytidine (3) (R1479) ( J. Biol. Chem. 2006 , 281 , 3793 ; Bioorg.
Med. Chem. Lett. 2007 , 17 , 2570 ) as a potent inhibitor of RNA synthesis by NS5B (EC 50 = …

4′-Azidocytidine 3 (R1479) has been previously discovered as a potent and selective
inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, …

Both preclinical evidence and clinical evidence suggest that α 7 nicotinic acetylcholine
receptor activation (α 7 nAChR) improves cognitive function, the decline of which is associated …

Treatment of (±)-l-[[(tert-butyldiphenylsilyl) oxy] methyl]-3-methoxycyclopent-l-ene (17) with
azidotrimethylsilane under Lewis acid catalyzed conditions gave an equilibrium mixture of …

Results Solid-State Structure. Suitable crystals for X-ray diffraction analyses were obtained
from an acetonitrile solution. A colorless crystal of dimensions 0.30 X 0.35 X 0. 45 mm was …

The genotoxins ethyl chloride (EtCl) and methyl chloride (MeCl) were generated during the
preparation of the hydrochloride salts of two tertiary amines in the presence of ethanol and …