User profiles for Hanoch Senderowitz
Hanoch SenderowitzProfessor of Chemistry, Bar-Ilan University Verified email at biu.ac.il Cited by 3110 |
Docking studies on DNA intercalators
Y Gilad, H Senderowitz - Journal of chemical information and …, 2014 - ACS Publications
DNA is an important target for the treatment of multiple pathologies, most notably cancer. In
particular, DNA intercalators have often been used as anticancer drugs. However, despite …
particular, DNA intercalators have often been used as anticancer drugs. However, despite …
[HTML][HTML] The cystic fibrosis-causing mutation ΔF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis
…, JL Mendoza, K Du, S Fischman, H Senderowitz… - Journal of Biological …, 2010 - ASBMB
The deletion of phenylalanine 508 in the first nucleotide binding domain of the cystic fibrosis
transmembrane conductance regulator is directly associated with >90% of cystic fibrosis …
transmembrane conductance regulator is directly associated with >90% of cystic fibrosis …
A smart Monte Carlo technique for free energy simulations of multiconformational molecules. Direct calculations of the conformational populations of organic …
H Senderowitz, F Guarnieri, WC Still - Journal of the American …, 1995 - ACS Publications
Metropolis Monte Carlo (MMC) can be a highly inefficient simulationtechmque when only a
small fraction of an energy surface is populated and barriers between low-energy regions are …
small fraction of an energy surface is populated and barriers between low-energy regions are …
Stability prediction for mutations in the cytosolic domains of cystic fibrosis transmembrane conductance regulator
…, CG Brouillette, JF Hunt, H Senderowitz - Journal of chemical …, 2021 - ACS Publications
Cystic Fibrosis (CF) is caused by mutations to the Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) chloride channel. CFTR is composed of two membrane spanning …
Regulator (CFTR) chloride channel. CFTR is composed of two membrane spanning …
Data Mining and Machine Learning Tools for Combinatorial Material Science of All‐Oxide Photovoltaic Cells
Growth in energy demands, coupled with the need for clean energy, are likely to make solar
cells an important part of future energy resources. In particular, cells entirely made of metal …
cells an important part of future energy resources. In particular, cells entirely made of metal …
[HTML][HTML] Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance …
…, I Sela-Culang, M Mense, H Senderowitz… - Journal of Biological …, 2012 - ASBMB
Deletion of Phe-508 (F508del) in the first nucleotide binding domain (NBD1) of the cystic
fibrosis transmembrane conductance regulator (CFTR) leads to defects in folding and channel …
fibrosis transmembrane conductance regulator (CFTR) leads to defects in folding and channel …
[HTML][HTML] A comparison and chemometric analysis of several molecular mechanics force fields and parameter sets applied to carbohydrates
…, A Bernardi, L Raimondi, H Senderowitz… - Carbohydrate …, 1998 - Elsevier
Carbohydrates are thought to be especially difficult to model because of their highly polar
functionality, their flexibility, and their differences in electronic arrangements that occur during …
functionality, their flexibility, and their differences in electronic arrangements that occur during …
[HTML][HTML] Plant phenolic volatiles inhibit quorum sensing in pectobacteria and reduce their virulence by potential binding to ExpI and ExpR proteins
Quorum sensing (QS) is a population density-dependent regulatory system in bacteria that
couples gene expression to cell density through accumulation of diffusible signaling …
couples gene expression to cell density through accumulation of diffusible signaling …
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
…, DR Wetmore, Y Marantz, H Senderowitz - Journal of computer …, 2010 - Springer
Folding correctors of F508del-CFTR were discovered by in silico structure-based screening
utilizing homology models of CFTR. The intracellular segment of CFTR was modeled and …
utilizing homology models of CFTR. The intracellular segment of CFTR was modeled and …
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives
…, J Eckel, E Cerasi, H Senderowitz… - Journal of medicinal …, 2013 - ACS Publications
Adenosine 5′-monophosphate activated protein kinase (AMPK) has emerged as a major
potential target for novel antidiabetic drugs. We studied the structure of 2-chloro-5-((Z)-((E)-5-((…
potential target for novel antidiabetic drugs. We studied the structure of 2-chloro-5-((Z)-((E)-5-((…