[PDF][PDF] Metabolite-sensing receptor Ffar2 regulates colonic group 3 innate lymphoid cells and gut immunity
…, D Fonseca-Pereira, S Bae, M Michaud, HR Hoveyda… - Immunity, 2019 - cell.com
Group 3 innate lymphoid cells (ILC3s) sense environmental signals that are critical for gut
homeostasis and host defense. However, the metabolite-sensing G-protein-coupled receptors …
homeostasis and host defense. However, the metabolite-sensing G-protein-coupled receptors …
Treatment of menopausal vasomotor symptoms with fezolinetant, a neurokinin 3 receptor antagonist: a phase 2a trial
…, S Ramael, J Combalbert, HR Hoveyda… - The Journal of …, 2019 - academic.oup.com
Context The thermoregulatory center in the hypothalamus is stimulated by neurokinin 3
receptor (NK3R) activation and inhibited by estrogen-negative feedback. This balance is …
receptor (NK3R) activation and inhibited by estrogen-negative feedback. This balance is …
The NK3 receptor antagonist ESN364 interrupts pulsatile LH secretion and moderates levels of ovarian hormones throughout the menstrual cycle
GL Fraser, HR Hoveyda, IJ Clarke… - …, 2015 - academic.oup.com
Women’s health disorders such as uterine fibroids and endometriosis are currently treated
by GnRH modulators that effectively suppress the hypothalamic-pituitary-gonadal axis. The …
by GnRH modulators that effectively suppress the hypothalamic-pituitary-gonadal axis. The …
Randomized controlled trial of neurokinin 3 receptor antagonist fezolinetant for treatment of polycystic ovary syndrome
…, J Combalbert, HR Hoveyda… - The Journal of …, 2021 - academic.oup.com
Context Polycystic ovary syndrome (PCOS), a highly prevalent endocrine disorder characterized
by hyperandrogenism, is the leading cause of anovulatory infertility. Objective This proof…
by hyperandrogenism, is the leading cause of anovulatory infertility. Objective This proof…
The NK3 receptor antagonist ESN364 suppresses sex hormones in men and women
GL Fraser, S Ramael, HR Hoveyda… - The Journal of …, 2016 - academic.oup.com
Context: Women's health disorders are commonly treated by agents that suppress the
hypothalamic-pituitary-gonadal axis. NK3 receptor antagonism modulates this axis with distinct …
hypothalamic-pituitary-gonadal axis. NK3 receptor antagonism modulates this axis with distinct …
Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): development of ulimorelin (TZP-101) from hit to clinic
HR Hoveyda, E Marsault, R Gagnon… - Journal of medicinal …, 2011 - ACS Publications
High-throughput screening of Tranzyme Pharma’s proprietary macrocycle library using the
aequorin Ca 2+ -bioluminescence assay against the human ghrelin receptor (GRLN) led to …
aequorin Ca 2+ -bioluminescence assay against the human ghrelin receptor (GRLN) led to …
Expression of free fatty acid receptor 2 by dendritic cells prevents their expression of interleukin 27 and is required for maintenance of mucosal barrier and immune …
…, CAG Comeau, JK Lang, M Michaud, HR Hoveyda… - Gastroenterology, 2020 - Elsevier
Background & Aims Intestinal microbes and their metabolites affect the development of colorectal
cancer (CRC). Short-chain fatty acids are metabolites generated by intestinal microbes …
cancer (CRC). Short-chain fatty acids are metabolites generated by intestinal microbes …
A three‐component reaction for diversity‐oriented synthesis of polysubstituted piperidines: solution and solid‐phase optimization of the first tandem aza [4+ 2] …
BB Toure, HR Hoveyda, J Tailor… - … A European Journal, 2003 - Wiley Online Library
This article describes the design and optimization of a simple three‐component aza[4+2]/allylboration
reaction to access polysubstituted α‐hydroxyalkyl piperidines in a highly …
reaction to access polysubstituted α‐hydroxyalkyl piperidines in a highly …
Discovery of a new class of macrocyclic antagonists to the human motilin receptor
E Marsault, HR Hoveyda, ML Peterson… - Journal of medicinal …, 2006 - ACS Publications
A novel class of macrocyclic peptidomimetics was identified and optimized as potent antagonists
to the human motilin receptor (hMOT-R). Well-defined structure−activity relationships …
to the human motilin receptor (hMOT-R). Well-defined structure−activity relationships …
Optimization of novel antagonists to the neurokinin-3 receptor for the treatment of sex-hormone disorders (part II)
HR Hoveyda, GL Fraser, G Dutheuil… - ACS Medicinal …, 2015 - ACS Publications
Further lead optimization on N-acyl-triazolopiperazine antagonists to the neurokinin-3
receptor (NK 3 R) based on the concurrent improvement in bioactivity and ligand lipophilic …
receptor (NK 3 R) based on the concurrent improvement in bioactivity and ligand lipophilic …