We report the annotation and analysis of the draft genome sequence of Brassica rapa accession
Chiifu-401-42, a Chinese cabbage. We modeled 41,174 protein coding genes in the B. …

A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation,
a feature associated with immune dysfunction. Here, we examined how CD8 + tumor …

Depleting regulatory T cells (T reg cells) to counteract immunosuppressive features of the
tumor microenvironment (TME) is an attractive strategy for cancer treatment; however, …

The differentiation of naive T-helper (Th) cells towards Th1 or Th2 cells is regulated by the
transcription factors T-box expressed in T-cells (T-bet) and GATA-binding protein-3 (GATA-3). …

Glutamine metabolism provides synergistic support for macrophage activation and elicitation
of desirable immune responses; however, the underlying mechanisms regulated by …

The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor
activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether …

We have isolated a cDNA from rat placenta which, when expressed heterologously, mediates
the transport of a wide spectrum of organic cations. The cDNA codes for a protein of 551 …

T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among
exhausted CD8 + tumor-infiltrating lymphocytes, the terminally exhausted subset contributes …

We report here on the cloning and functional characterization of human LAT1, a subunit of
the amino acid transport system L. The hLAT1 cDNA, obtained from a human placental cDNA …

Previous studies have shown that a Na + -dependent transport system is responsible for the
transplacental transfer of the vitamins pantothenate and biotin and the essential metabolite …