PTEN is a phosphatase which metabolises PIP 3 , the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly, …

Loss of function of the PTEN tumour suppressor, resulting in dysregulated activation of the
phosphoinositide 3-kinase (PI3K) signalling network, is recognized as one of the most …

Orthopedic implants containing biodegradable magnesium have been used for fracture repair
with considerable efficacy; however, the underlying mechanisms by which these implants …

The northern spotted owl (Strix occidentalis caurina) inhabits older coniferous forests in the
Pacific Northwest and has been at the center of forest management issues in this region. The …

Influenza A virus (IAV) infection leads to variable and imperfectly understood pathogenicity.
We report that segment 3 of the virus contains a second open reading frame (“X-ORF”), …

The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus
can spread and the ability of a generally mild infection to induce severe morbidity and …

Four types of carbon were observed to form on an alumina-supported nickel methanation
catalyst on exposure to carbon monoxide at 550 ± 50 K. In order of their reactivity toward …

Influenza A virus segment 2 is known to encode two polypeptides in overlapping open reading
frames: PB1, the polymerase, and PB1-F2, a proapoptotic virulence factor. We show that …

Segment 7 of influenza A virus produces up to four mRNAs. Unspliced transcripts encode M1,
spliced mRNA2 encodes the M2 ion channel, while protein products from spliced mRNAs …

Objectives. To evaluate prostate cancer detection and prostate-specific antigen (PSA) among
men with benign prostatic hyperplasia treated with finasteride. Methods. Three thousand …