Background: Concerns for arsenic exposure are not limited to toxic waste sites and massive
poisoning events. Chronic exposure continues to be a major public health problem …

A meeting on the health effects of arsenic (As), its modes of action, and areas in need of future
research was held in Hunt Valley, Maryland, on 22-24 September 1997. Exposure to As in …

▪ Abstract Arsenic metabolism has typically been studied by administering arsenate or
arsenite into animals and humans and then studying the metabolites excreted in the urine. …

Methylation has been considered to be the primary detoxication pathway of inorganic arsenic.
Inorganic arsenic is methylated by many, but not all animal species, to monomethylarsonic …

Monomethylarsonous acid (MMA III ), a metabolite of inorganic arsenic, has received very
little attention from investigators of arsenic metabolism in humans. MMA III , like sodium …

Biomethylation is the major human metabolic pathway for inorganic arsenic, and the speciation
of arsenic metabolites is essential to a better understanding of arsenic metabolism and …

This article reviews the pharmacological properties and the uses of two important antidotes
for heavy metal poisoning. Meso-dimercaptosuccinic acid (DMSA) and 2, 3-dimercapto-l-…

… for I1 h before DMP!3 administration and determining the mercury content per II h and then
calculating the mercury excretion per h. R = coefficient of correlation (Aposhian et al., 1992). …

This laboratory has studied the enzymology involved in the biotransformation of inorganic
arsenic to dimethylarsinous acid (DMA(III)) and in human studies established that …

Monomethylarsonous acid (MMA III ) has been detected for the first time in the urine of some
humans exposed to inorganic arsenic in their drinking water. Our experiments have dealt …