It is well established that the continued intake of drugs of abuse is reinforcing—that is repeated
consumption increases preference. This has been shown in some studies to extend to …

Schizophrenia is characterized by cognitive deficits which persist after acute symptoms have
been treated or resolved. Transcranial direct current stimulation (tDCS) has been reported …

Several lines of schizophrenia (SZ) research suggest that a functional downregulation of the
prefrontal cortex GABAergic neuronal system is mediated by a promoter hypermethylation, …

… We report here saturation analysis of [ 3 H]cocaine binding in various mouse brain regions,
… [ 3 h]-cocaine binding and [ 3 H]dopamine uptake in the mouse striatum, and to inhibit [ 3 H]…

Synaptic roles for neurofilament (NF) proteins have rarely been considered. Here, we
establish all four NF subunits as integral resident proteins of synapses. Compared with the …

We studied the effect of local administration of nicotine on the release of monoamines in
striatum, substantia nigra, cerebellum, hippocampus, cortex (frontal, cingulate), and pontine …

… (NFPS) produced biphasic inhibition of [3 H] glycine transport, with IC 50 values of … 3 H]
MeAIB was monophasic with a single IC 50 value of 31 μM. Clozapine significantly inhibited [3 H] …

Tau pathogenicity in Alzheimer9s disease and other tauopathies is thought to involve the
generation of hyperphosphorylated, truncated, and oligomeric tau species with enhanced …

OBJECTIVE: Varenicline has been shown to be an effective anti-smoking treatment in smokers
without identified psychiatric illness, and the drug's pharmacology suggests possibilities …

Nicotine, one of the most widespread drugs of abuse, has long been shown to impact areas
of the brain involved in addiction and reward. Recent research, however, has begun to …