Peroxisomal fatty acid degradation in the yeast Saccharomyces cerevisiae requires an
array of β-oxidation enzyme activities as well as a set of auxiliary activities to provide the β-…

Unicellular organisms such as yeast constantly monitor their environment and respond to
nutritional cues. Rapid adaptation to ambient changes may include modification and …

Peroxisomes perform a range of metabolic functions which require the movement of
substrates, co-substrates, cofactors and metabolites across the peroxisomal membrane. In this …

Targeting of peroxisomal membrane proteins (PMPs) is a multistep process that requires
not only recognition of PMPs in the cytosol but also their insertion into the peroxisomal …

The requirement for small molecule transport systems across the peroxisomal membrane
has previously been postulated, but not directly proven. Here we report the identification and …

Rapid vascular recanalization forms the basis for successful treatment of cerebral ischemia.
Currently, tissue plasminogen activator (t-PA) is the only approved thrombolytic drug for …

Gene therapy has the potential to maintain therapeutic blood clotting factor IX (FIX) levels in
patients with hemophilia B by delivering a functional human F9 gene into liver cells. This …

ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin motif repeats 13)
has antithrombotic properties because it cleaves von Willebrand factor (VWF) in smaller, less …

A longer acting recombinant FVIII is expected to serve patients’ demand for a more convenient
prophylactic therapy. We have developed BAX 855, a PEGylated form of Baxter’s rFVIII …

Coronary heart disease is a major cause of death in the western world. Although essential
for successful recovery, reperfusion of ischemic myocardium is inevitably associated with …