[HTML][HTML] Flavonoids as protectors against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductase

H Kaiserová, T Šimůnek, WJF van Der Vijgh… - … et Biophysica Acta (BBA …, 2007 - Elsevier
… We found that after 24 h incubation of the cells with 1 μM of doxorubicin and 100 μM of
the flavonoids, four compounds (F4, F5, F7, F10) offered more than 40% protection, four …

New iron chelators in anthracycline-induced cardiotoxicity

H Kaiserová, T Šimůnek, M Štěrba… - Cardiovascular …, 2007 - Springer
… Ferrous-ammonium sulfate was pre-reacted with a fluorescent probe calcein for 1 h (quenching
of fluorescence), after which the chelators at 5 μM concentration (final) were added and …

Protectors against doxorubicin-induced cardiotoxicity: Flavonoids

A Bast, H Kaiserová, GJM Den Hartog… - Cell biology and …, 2007 - Springer
Doxorubicin is a widely used anthracycline anticancer agent. Its use may cause cardiomyopathy:
in fact, the development of cumulative dose-related cardiotoxicity forms the major …

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

…, M Štěrba, O Popelova, H Kaiserova… - British journal of …, 2008 - Wiley Online Library
Background and purpose: The clinical utility of anthracycline antineoplastic drugs is limited
by the risk of cardiotoxicity, which has been traditionally attributed to iron‐mediated …

Iron is not involved in oxidative stress‐mediated cytotoxicity of doxorubicin and bleomycin

H Kaiserova, GJM Den Hartog… - British journal of …, 2006 - Wiley Online Library
Background and purpose: The anticancer drugs doxorubicin and bleomycin are well‐known
for their oxidative stress‐mediated side effects in heart and lung, respectively. It is frequently …

Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity

…, A Potáčová, M Adamcová, H Kaiserová… - … of Pharmacology and …, 2006 - ASPET
Iron chelation is the only pharmacological intervention against anthracycline cardiotoxicity
whose effectiveness has been well documented both experimentally and clinically. In this …

Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: a study of salicylaldehyde isonicotinoyl hydrazone (SIH)

…, A Potáčová, M Adamcová, I Gunčová, H Kaiserová… - Toxicology, 2007 - Elsevier
Pyridoxal-derived aroylhydrazone iron chelators have been previously shown as effective
cardioprotectants against chronic anthracycline cardiotoxicity. In this study we focused on a …

In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

M Adamcová, T Šimůnek, H Kaiserová, O Popelová… - Toxicology, 2007 - Elsevier
… Culture medium was sampled at 0 h, 3 h, 6 h, 12 h, 24 h, 48 h and 72 h of daunorubicin
exposure for determinations of cTnT, cTnI and the activity of lactate dehydrogenase (LDH) as a …

[PDF][PDF] The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics …

L Schroterova, H Kaiserova, V Baliharova, J Velik… - Physiol Res, 2004 - biomed.cas.cz
A major obstacle to the therapeutic use of anthracyclines, highly effective anticancer agents,
is the fact that their administration results in dose-dependent cardiomyopathy. According to …

Pyridoxal isonicotinoyl hydrazone (PIH) and its analogs as protectants against anthracycline-induced cardiotoxicity

T Simunek, M Sterba, O Popelova, H Kaiserova… - …, 2008 - Taylor & Francis
The risk of cardiotoxicity is the main drawback of anthracycline antibiotics. However, these
drugs remain among the most effective and frequently used anti cancer drugs. In this study we …