[HTML][HTML] Training vs. Tolerance: the yin/yang of the innate immune system

…, J Hebel, M Bartosova, D Frommhold, H Hudalla… - Biomedicines, 2023 - mdpi.com
For almost nearly a century, memory functions have been attributed only to acquired immune
cells. Lately, this paradigm has been challenged by an increasing number of studies …

[HTML][HTML] The role of microbiota in neutrophil regulation and adaptation in newborns

T Lajqi, J Pöschl, D Frommhold, H Hudalla - Frontiers in Immunology, 2020 - frontiersin.org
… Neutrophils are terminally differentiated cells mainly characterized by a short lifespan (around
48 h after release into the circulation) (2, 3). They are involved in the defense against …

[PDF][PDF] Efficacy of Bifidobacterium longum, B. infantis and Lactobacillus acidophilus probiotics to prevent gut dysbiosis in preterm infants of 28+0–32+6 weeks of …

…, C Gille, S Goedicke-Fritz, W Goepel, H Hudalla… - BMJ open, 2019 - academia.edu
Introduction The healthy ‘eubiosis’ microbiome in infancy is regarded as the microbiome
derived from term, vaginally delivered, antibiotic free, breastfed infants at 4–6 months. Dysbiosis …

Carbonic anhydrase inhibition ameliorates inflammation and experimental pulmonary hypertension

H Hudalla, Z Michael, N Christodoulou… - American Journal of …, 2019 - atsjournals.org
… CAs have an essential metabolic regulatory role by catalyzing the conversion of CO 2
and H 2 O to H 2 CO 3 , thereby facilitating CO 2 removal. In the setting of CA inhibition, …

[HTML][HTML] Memory-like inflammatory responses of microglia to rising doses of LPS: key role of PI3Kγ

…, GP Lang, F Haas, DL Williams, H Hudalla… - Frontiers in …, 2019 - frontiersin.org
… Six h and 24 h after the second stimulation, samples have … h and rechallenged on day 6
with a fixed dose of LPS (100 ng/ml). Supernatants and protein lysates have been collected 24 h

LPS-induced maternal inflammation promotes fetal leukocyte recruitment and prenatal organ infiltration in mice

H Hudalla, K Karenberg, RJ Kuon, J Pöschl… - Pediatric …, 2018 - nature.com
Background A pro-inflammatory intrauterine milieu accounts for increased perinatal morbidity
and mortality. We asked how maternal inflammation as seen in endotoxemia affects fetal …

[HTML][HTML] Gut microbiota-derived small extracellular vesicles endorse memory-like inflammatory responses in murine neutrophils

…, J Rühle, D Frommhold, J Pöschl, C Gille, H Hudalla - Biomedicines, 2022 - mdpi.com
… Resting cells were re-challenged 18 h after the priming step with LPS (100 ng/mL) for 4 h.
Low concentration (1 ng/mL) sEV priming led to elevated levels of IL-6 and TNF-α contrary to …

Meconium microbiome of very preterm infants across Germany

…, K Hilbert, A Haiß, J Marißen, P Henneke, H Hudalla… - MSphere, 2022 - Am Soc Microbiol
Meconium constitutes infants' first bowel movements postnatally. The consistency and
microbial load of meconium are different from infant and adult stool. While recent evidence …

[HTML][HTML] Memory-like responses of brain microglia are controlled by developmental state and pathogen dose

T Lajqi, M Stojiljkovic, DL Williams, H Hudalla… - Frontiers in …, 2020 - frontiersin.org
… RNA samples (6 h) and supernatants (24 h) were collected after the 2nd stimulation and
analyzed for gene expression of TNF-α (* indicates time point of sample collection). (B) (n = 5–6)…

[HTML][HTML] Challenges in acceptance and compliance in digital health assessments during pregnancy: prospective cohort study

…, TM Deutsch, H Hudalla, H Abele… - JMIR mHealth and …, 2020 - mhealth.jmir.org
Background: Pregnant women are increasingly using mobile apps to access health information
during the antenatal period. Therefore, digital health solutions can potentially be used as …