The immunology of asthma

BN Lambrecht, H Hammad - Nature immunology, 2015 - nature.com
… switching from a predominant T H 2 response to T H 1 and/or T H 17 response(s) 82 . Some
… produce both T H 17 cytokines and T H 2 cytokines. In mice, these IL-4 + T H 17 cells induce …

[PDF][PDF] The basic immunology of asthma

H Hammad, BN Lambrecht - Cell, 2021 - cell.com
In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-producing
Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease such as …

[PDF][PDF] Barrier epithelial cells and the control of type 2 immunity

H Hammad, BN Lambrecht - Immunity, 2015 - cell.com
Type-2-cell-mediated immunity, rich in eosinophils, basophils, mast cells, CD4 + T helper 2 (Th2)
cells, and type 2 innate lymphoid cells (ILC2s), protects the host from helminth infection …

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

H Hammad, M Chieppa, F Perros, MA Willart… - Nature medicine, 2009 - nature.com
… We next evaluated the amounts of the prototypical T H 1, T H 2 and T H 17 cytokines (interferon-γ
(IFN-γ), IL-5 and IL-17, respectively) produced by MLN cells. Very low concentrations of …

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

…, S Jung, HC Hoogsteden, H Hammad… - The Journal of …, 2008 - rupress.org
… We indeed observed that 2 h after injection of OVA-AF647 with or without alum, the MLN
subcapsular sinus and B cell area became strongly fluorescent when we imaged sections …

Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen

HJ De Heer, H Hammad, T Soullié, D Hijdra… - The Journal of …, 2004 - rupress.org
… Draining MLNs were excised 36 h later and analyzed by flow … sorted from the MLNs 36 h
later and cocultured with purified … 48 h by [ 3 H]thymidine (1 μCi/well) uptake in a 16-h pulse. …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

…, C Haftmann, J Hahn, H Hammad… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical aspects of …

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

…, K Deswarte, B Malissen, H Hammad… - Journal of Experimental …, 2013 - rupress.org
… Guilliams, and by a FWO project grant to H. Hammad. I. De Kleer is the recipient of a European
Respiratory Society/Marie Curie Joint Research Fellowship number MC 1231-2009 and …

The airway epithelium in asthma

BN Lambrecht, H Hammad - Nature medicine, 2012 - nature.com
… cells and induce T H 2, T H 17 and T follicular helper (T FH ) differentiation. This T H polarization
is … Basophils are an important source of IL-4, which further supports T H 2 development …

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

M Idzko, H Hammad, M Van Nimwegen, M Kool… - Nature medicine, 2007 - nature.com
… subjects 10 min and 24 h after segmental airway challenge with saline … In contrast, 24 h after
allergen provocation the ATP … At 24 h after the last challenge, the concentration of ATP was …