[HTML][HTML] M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase

H Glantschnig, JE Fisher, G Wesolowski… - Cell Death & …, 2003 - nature.com
… 24 h of culture and that ALN effects are not seen until 48 h or more. We therefore examined
rapamycin effects at 72 and 96 h… During the first 72 h, dose-dependent inhibition of up to 60% …

[HTML][HTML] Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins

E Luegmayr, H Glantschnig, GA Wesolowski… - Cell Death & …, 2004 - nature.com
Osteoporosis is associated with both atherosclerosis and vascular calcification. No
mechanism yet explains the parallel progression of these diseases. Here, we demonstrate that …

The regulatory role of thyroid hormones in bone cell growth and differentiation

K Klaushofer, F Varga, H Glantschnig… - The Journal of …, 1995 - Elsevier
The clinical effects of thyroid hormones on bone in hypo- and hyperthyroidism are well known
but their fundamental role in the regulation of bone remodeling is still poorly understood. …

[HTML][HTML] Mapping of MST1 kinase sites of phosphorylation: activation and autophosphorylation

H Glantschnig, GA Rodan, AA Reszka - Journal of Biological Chemistry, 2002 - ASBMB
… -dishes and allowed to adhere for at least 8 h or overnight before transfection. Cells were
transfected … Cultures were then maintained for at least 18 h before protein lysates were made. …

[HTML][HTML] Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in …

H Glantschnig, RA Hampton, P Lu, JZ Zhao… - Journal of Biological …, 2010 - ASBMB
Wnt/LRP5 signaling is a central regulatory component of bone formative and resorptive
activities, and the pathway inhibitor DKK1 is a suppressor of bone formation and bone mass …

A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an …

H Glantschnig, K Scott, R Hampton, N Wei… - … of Pharmacology and …, 2011 - ASPET
… Plates then were incubated at room temperature for 1.5 h. After being blocked, each well
was washed three times with PBST, then dried, sealed, and stored at 4C. All of the serum …

Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents

…, J Miao, SE Alves, H Glantschnig… - … Series A: Biomedical …, 2013 - academic.oup.com
Myostatin is a highly conserved member of the transforming growth factor-β ligand family
known to regulate muscle growth via activation of activin receptors. A fusion protein consisting …

Triiodothyronine, a regulator of osteoblastic differentiation: depression of histone H4, attenuation of c-fos/c-jun, and induction of osteocalcin expression

…, E Luegmayr, N Fratzl-Zelman, H Glantschnig… - Calcified tissue …, 1997 - Springer
Thyroid hormones influence growth and differentiation of bone cells. In vivo and in vitro data
indicate their importance for development and maintenance of the skeleton. …

[HTML][HTML] Evidence of protective effects of recombinant ADAMTS13 in a humanized model of sickle cell disease

P Rossato, E Federti, H Glantschnig, F Canneva… - …, 2022 - ncbi.nlm.nih.gov
H/R) stress as a model of vaso-occlusive crisis. In SCD mice, recombinant ADAMTS13 reduced
H… It also diminished H/R-induced worsening of inflammatory vasculopathy, reducing local …

[HTML][HTML] Treatment with recombinant ADAMTS13, alleviates hypoxia/reoxygenation-induced pathologies in a mouse model of human sickle cell disease

P Rossato, H Glantschnig, F Canneva… - Journal of Thrombosis …, 2023 - Elsevier
… SCD mice were treated with rADAMTS13 and exposed to H/R … We observed alleviated
H/R-related effects on behavioral … The behavioral score was 0 for all H/R-challenged humanized …