Targeted tissue delivery of RNA therapeutics using antibody–oligonucleotide conjugates (AOCs)

…, CD Miller, H Huang, A Geall, HS Younis… - Nucleic Acids …, 2023 - academic.oup.com
Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated
in rodents, effectiveness and pharmacokinetic/pharmacodynamic (PKPD) properties …

Structural basis of the antagonism between inorganic mercury and selenium in mammals

…, EY Yu, MB Denton, HS Younis… - Chemical Research …, 2000 - ACS Publications
Mercuric chloride toxicity in mammals can be overcome by co-administration of sodium
selenite. We report a study of the mutual detoxification product in rabbit plasma, and of a Hg−Se−…

A Metabolic Link between Arsenite and Selenite:  The Seleno-bis(S-glutathionyl) Arsinium Ion

…, JE Pemberton, RS Glass, HS Younis… - Journal of the …, 2000 - ACS Publications
Among the most startling observations in mammalian toxicology is that a lethal dose of selenium
can be overcome by an otherwise lethal dose of arsenic. We report the molecular basis …

Identification and characterization of modified antisense oligonucleotides targeting DMPK in mice and nonhuman primates for the treatment of myotonic dystrophy type …

…, TM Wheeler, SL Justice, A Kim, HS Younis… - … of Pharmacology and …, 2015 - ASPET
Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults.
DM1 is caused by an expanded CTG repeat in the 3′-untranslated region of DMPK, the …

[HTML][HTML] Integrated safety assessment of 2′-O-methoxyethyl chimeric antisense oligonucleotides in nonhuman primates and healthy human volunteers

…, N Salgado, HH Bui, CE Hart, SA Burel, HS Younis… - Molecular Therapy, 2016 - cell.com
… Husam S Younis Husam S Younis … -blind, randomized trial of a second generation antisense
oligonucleotide targeting high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis. …

Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys

HS Younis, J Crosby, JI Huh, HS Lee… - Blood, The Journal …, 2012 - ashpublications.org
A strategy to produce sufficient anticoagulant properties with reduced risk of bleeding may
be possible through inhibition of factor XI (FXI), a component of the intrinsic coagulation …

Recommendations for safety pharmacology evaluations of oligonucleotide-based therapeutics

…, SZ Sun, J Tepper, G Waldron, HS Younis - Nucleic acid …, 2014 - liebertpub.com
This document was prepared by the Safety Pharmacology Subcommittee of the Oligonucleotide
Safety Working Group (OSWG), a group of industry and regulatory scientists involved in …

PD0325901, a mitogen-activated protein kinase kinase inhibitor, produces ocular toxicity in a rabbit animal model of retinal vein occlusion

…, L Marroquin, M Ko, S Aguirre, HS Younis - Journal of Ocular …, 2009 - liebertpub.com
Objective: PD0325901, a selective inhibitor of mitogen-activated protein kinase kinase (MEK),
was associated with the occurrence of ocular retinal vein occlusion (RVO) during clinical …

Biliary Excretion of [(GS)2AsSe]- after Intravenous Injection of Rabbits with Arsenite and Selenate

…, IJ Pickering, RC Prince, HS Younis… - Chemical research in …, 2002 - ACS Publications
It has been shown that the seleno-bis (S-glutathionyl) arsinium ion, [(GS) 2 AsSe] - , is the
major arsenic and selenium excretory product in bile of rabbits treated with arsenite and …

Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system

…, SS Devi, E Sparkenbaugh, HS Younis… - Toxicological …, 2009 - academic.oup.com
Sulindac (SLD) is a nonsteroidal anti-inflammatory drug (NSAID) that has been associated
with a greater incidence of idiosyncratic hepatotoxicity in human patients than other NSAIDs. …