Close to half of the human genome encompasses mobile genetic elements, most of which
are retrotransposons. These genetic invaders are formidable evolutionary forces that have …

Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be
functionally equivalent to the inner cell mass, which lacks the ability to produce all …

More than forty per cent of the mammalian genome is derived from retroelements, of which
about one-quarter are endogenous retroviruses (ERVs) 1 . Some are still active, notably in …

Cleanroom processing techniques have been used to mass-produce flexible,
electroenzymatic glucose sensors designed for implantation in subcutaneous tissue. In vitro …

Over half of our genome is composed of retrotransposons, which are mobile elements that
can readily amplify their copy number by replicating through an RNA intermediate. Most of …

Francisella tularensis is a highly-infectious bacterium that causes the rapid, and often lethal
disease, tularemia. Many studies have been performed to identify and characterize the …

KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of
transposable elements (TEs), which they repress with their cofactor KAP1 through histone and …

11-Hydroxy-Δ 9 -tetrahydrocannabinol, administered intravenously to man, produces psychologic
and pharmacologic effects that persist for several hours. The drug and its metabolites …

TRIM28 is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES)
cells. Here, we reveal that an essential impact of this process is the protection of cellular …

… As we have previously found ERVs to be regulated by KAP1 in mouse ES cells but not in
MEFs (Rowe et al., 2010), we hypothesized that this difference may correlate with the …