Among the diverse sets of nicotinic acetylcholine receptors (nAChRs), the α7 subtype is
highly expressed in the hippocampus and cortex and is thought to play important roles in a …

The α7 nicotinic acetylcholine receptor (nAChR) plays an important role in cognitive processes
and may represent a drug target for treating cognitive deficits in neurodegenerative and …

10.7554/eLife.42940.001 The integrated stress response (ISR) attenuates the rate of protein
synthesis while inducing expression of stress proteins in cells. Various insults activate …

The discovery of a series of pyrrole-sulfonamides as positive allosteric modulators (PAM) of
α7 nAChRs is described. Optimization of this series led to the identification of 19 (A-867744), …

Cardiac output may be an important determinant of the induction dose of intravenous anaesthetic.
Esmolol is known to reduce cardiac output, and we examined its effect on the propofol …

Blockade of the histamine H 3 receptor (H 3 R) enhances central neurotransmitter release,
making it an attractive target for the treatment of cognitive disorders. Here, we present in vitro …

This prospective, randomised double‐blinded study was designed to assess the analgesic
efficacy and occurrence of nausea when tramadol is added to a nonsteroidal anti‐…

Preclinical assessment of pain has typically relied on measuring animal responses to evoked
stimulation. Because of inherent limitations of these assays, there is a need to develop …

We have studied the effectiveness and sequelae of low-dose suxamethonium in 60 day-case
oral surgery patients requiring nasal intubation. Anaesthesia was induced with propofol …

In a double-blind, placebo-controlled clinical trial (power of 80% to detect a 30% reduction
in morphine consumption, P<0.05) we have determined that intraoperative intravenous …