A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …

Context Formalin fixation and paraffin embedding is a timeless, cost-efficient, and widely
adopted method of preserving human tissue biospecimens that has resulted in a substantial …

Context.—While formalin fixation and paraffin embedding has become a universal
mechanism of tissue preservation and a gold standard for immunohistochemistry, fixation and …

Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund,
was established to study the correlation between human genetic variation and tissue-specific …

(NCI) and its partners in collecting high quality post-mortem biospecimens for a major
National Institutes of Health (NIH) research program, the Genotype-Tissue Expression (GTEx) …

Human biospecimens are subject to a number of different collection, processing, and storage
factors that can significantly alter their molecular composition and consistency. These …

Accurate prediction of the functional effect of genetic variation is critical for clinical genome
interpretation. We systematically characterized the transcriptome effects of protein-truncating …

We define the activity and mechanisms of action of a small molecule lead compound for
cancer targeting. We show that the compound, BMH-21, has wide and potent antitumorigenic …

Objectives To review the first 50 patients to receive extracorporeal membrane oxygenation (ECMO)
for respiratory failure at Glenfield Hospital, and to compare them with published …