This white paper provides a critical analysis of methods for estimating transporter kinetics
and recommendations on proper parameter calculation in various experimental systems. …

Breast cancer resistance protein (BCRP; ABCG2) limits intestinal absorption of low-permeability
substrate drugs and mediates biliary excretion of drugs and metabolites. Based on …

… Previously, it has been demonstrated that H+ causes a contact-induced leakage from … values
of 5.0 or below (Ellens et al., 1984). Here we show that there is H+-induced mixing of lipids …

Harma Ellens, Joe Bentz, and Francis C. Szoka* abstract: The mechanism of pH-induced
destabilization of liposomes composed of phosphatidylethanolamine and a charged …

… Further details on all these procedures can be found in Ellens et … to Hn phase precursors
upon contact (Ellens et al., 1986a,b). At 60 … At 55 C (<7'H), we see no significant change in NBD …

We developed self-emulsifying water-in-oil (w/o) microemulsions incorporating medium-chain
glycerides and measured their conductance, viscosity, refractive index and particle size. …

The gastrointestinal tract provides a variety of morphological (eg epithelial cells, mucus)
and physiological (eg enzymes, pH, transporters) barriers to the absorption of peptides and …

A P-glycoprotein (P-gp) IC 50 working group was established with 23 participating
pharmaceutical and contract research laboratories and one academic institution to assess …

… the OATP1B1 probe substrate [ 3 H]-estradiol 17β-D-glucuronide ([ 3 H]-EG) by pazopanib
… The cell monolayers were used 2 days after seeding and induced for at least 24 h before use …

Drug-induced liver injury is the most common cause of market withdrawal of pharmaceuticals,
and thus, there is considerable need for better prediction models for DILI early in drug …