The discovery and synthesis of potential and novel antipsychotic coumarin derivatives,
associated with potent dopamine D 2 , D 3 , and serotonin 5-HT 1A and 5-HT 2A receptor …

Root lodging poses a major threat to maize production, resulting in reduced grain yield and
quality, and increased harvest costs. Here, we combined expressional, genetic, and …

Increasing planting density has been adopted as an effective means to increase maize (Zea
mays) yield. Competition for light from neighbors can trigger plant shade avoidance …

The superoxide dismutase 1 (SOD1) mutation is one of the most notable causes of amyotrophic
lateral sclerosis (ALS), and modifying the mutant SOD1 gene is the best approach for the …

Haploinsufficiency of the protein kinase Tbk1 has shown to cause both amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD); however, the pathogenic mechanisms …

The complex drug delivery barrier in the eye reduces the bioavailability of many drugs, resulting
in poor therapeutic effects. It is necessary to investigate new drugs through appropriate …

Herein, a novel series of multireceptor ligands was developed as polypharmacological
antipsychotic agents using the designed multiple ligand approach between dopamine receptors …

The discovery and synthesis of a new series of pyrimidines as potent sigma-1 receptor (σ 1
R) antagonists, associated with pharmacological antineuropathic pain activity, are the focus …

Opioid analgesics are highly effective painkillers for the treatment of moderate or severe
pain, but they are associated with a number of undesirable adverse effects, including the …

… Jingyang Wu, 1 Yifan Zhong, 1 Song Yue, 1 Kaibo Yang, 1 Guisen Zhang , … Correspondence
should be addressed to Guisen Zhang; zhangguisen76@sohu.com and Lei Liu; liuleijiao@…