α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

…, L Fu, S Jayaraman, MC Hu, OW Moe, G Liang… - Nature, 2018 - nature.com
The ageing suppressor α-klotho binds to the fibroblast growth factor receptor (FGFR). This
commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and …

Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents

G Liang, L Shao, Y Wang, C Zhao, Y Chu, J Xiao… - Bioorganic & medicinal …, 2009 - Elsevier
Curcumin has a surprisingly wide range of chemo-preventive and chemo-therapeutic
activities and is under investigation for the treatment of various human cancers. However, the …

[PDF][PDF] Cholangiocyte‐derived exosomal long noncoding RNA H19 promotes hepatic stellate cell activation and cholestatic liver fibrosis

…, Y Wang, D Zhao, X Wang, EC Gurley, G Liang… - …, 2019 - Wiley Online Library
Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the
progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte…

Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose–induced inflammation and apoptosis in cardiomyocytes and the development of …

…, J Zhang, S Zhou, Q Liu, X Li, L Cai, G Liang - Diabetes, 2014 - Am Diabetes Assoc
Hyperglycemia-induced inflammation and apoptosis have important roles in the pathogenesis
of diabetic cardiomyopathy. We recently found that a novel curcumin derivative, C66, is …

Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin

G Liang, X Li, L Chen, S Yang, X Wu, E Studer… - Bioorganic & medicinal …, 2008 - Elsevier
Curcumin has been extensively studied for its anti-inflammatory activities. However, its
potential beneficial effects on various disease preventions and treatments are limited by its …

Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents

…, Y Zhang, Y Zhao, S Yang, X Li, G Liang - Journal of medicinal …, 2011 - ACS Publications
Major anti-inflammatory agents, steroids and cyclooxygenase, were proved to have serious
side effects. Here, a series of chalcone derivatives were synthesized and screened for anti-…

Harvesting waste heat with flexible Bi2Te3 thermoelectric thin film

…, M Li, LZ Kou, YX Chen, F Li, M Wei, GX Liang… - Nature …, 2023 - nature.com
Thermoelectric materials offer the possibility of harvesting huge amounts of waste heat, such
as vehicle exhaust gases, and converting them directly into useful electricity, a process that …

Heterojunction annealing enabling record open‐circuit voltage in antimony triselenide solar cells

…, JT Luo, P Fan, XH Zhang, J Tang, GX Liang - Advanced …, 2022 - Wiley Online Library
Despite the fact that antimony triselenide (Sb 2 Se 3 ) thin‐film solar cells have undergone
rapid development in recent years, the large open‐circuit voltage (V OC ) deficit still remains …

Novel Thermal Diffusion Temperature Engineering Leading to High Thermoelectric Performance in Bi2Te3‐Based Flexible Thin‐Films

…, B Jabar, F Li, XL Shi, ZH Zheng, GX Liang… - Advanced …, 2022 - Wiley Online Library
Flexible Bi 2 Te 3 ‐based thermoelectric devices can function as power generators for
powering wearable electronics or chip‐sensors for internet‐of‐things. However, the unsatisfied …

Assembly‐free fabrication of high‐performance flexible inorganic thin‐film thermoelectric device prepared by a thermal diffusion

…, M Wei, YM Zhong, M Li, GX Liang… - Advanced Energy …, 2022 - Wiley Online Library
High relative contact electrical resistance and poor flexibility in inorganic thin‐film thermoelectric
devices significantly limit their practical applications. To overcome this challenge, a one‐…