In vivo receptor occupancy of mGlu5 receptor antagonists was quantified in rat and mouse
brain using the mGlu5 receptor selective antagonist [ 3 H]3-methoxy-5-(pyridin-2-ylethynyl)…

Missense mutations in the β-amyloid precursor protein gene (APP) co-segregate with a
small subset of autosomal dominant familial Alzheimer's disease (FAD) cases wherein …

A primary pathological feature of Alzheimer's disease is β-amyloid (Aβ)-containing plaques
in brain and cerebral vasculature. Reductions in the formation of Aβ peptides by γ-secretase …

The binding of [ 3 H]methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (methoxymethyl-MTEP),
a potent and selective antagonist for metabotropic glutamate (mGlu)5 receptors…

Dosage imbalance for chromosome 21 in Down syndrome and mutations in the amyloid
precursor protein (APP) and presenilin-1 (PS-1) genes in early-onset familial Alzheimer's …

Recent studies in mice have clearly demonstrated that eliminating Apo E alters the rate,
character and distribution of Aβ deposits. In the present study, we asked whether elevating the …

The coat protein of the small RNA virus MS2 shows charge heterogeneity in vivo. In most
strains there is a basic satellite of the native protein. We have shown that this basic satellite is …

Insulin-like growth factor-1 (IGF-1), a naturally occurring, relatively short, single chain polypeptide,
is prepared by growing methylotrophic yeast transformants containing in their genome …

Basal-level misreading of asparagine codons was examined in a number of Escherichia
coli strains. Lysine substitutions were measured by quantitating the amount of charge …

Structure–activity relationship studies performed around 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile
for the purpose of developing novel mGlu5 receptor antagonists are …