Inhibition of activation of nuclear factor κB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root

YJ Kang, YS Lee, GW Lee, DH Lee, JC Ryu… - … of Pharmacology and …, 1999 - ASPET
Effects of higenamine on nitric oxide (NO) production and inducible NO synthase (iNOS)
mRNA expression (RAW 264.7 cells), on vascular reactivity in vitro and in vivo (rats), and on …

Comparison of relaxations evoked by photoactivation of NO-containing compounds and nitrergic nerve stimulation in 5-hydroxytryptamine-and potassium-contracted …

…, EB Koo, GW Lee, YJ Kang, HY Lee - … : The Vascular System, 1998 - Elsevier
The aim of the present study was to further investigate our earlier proposal of liberation of
nitric oxide (NO) by photoactivation of molecules containing NO or NO 2 , which in turn relaxes …

Pharmacological Mechanism of Action of GS283 and GS386 on Human Platelet and Pig Coronary Artery

KC CHANG, HY LEE, GW LEE, EB KOO… - Biomolecules & …, 1997 - koreascience.kr
Trimetoquinol (TMQ) and its analogs are known to have thromboxane $ A_2 $ antagonistic
action. We also reported that GS389, chemically similar to TMQ, has competitive antagonistic …

Combined phototherapy with metabolic reprogramming-targeted albumin nanoparticles for treating breast cancer

XT Le, J Lee, NT Nguyen, WT Lee, ES Lee… - Biomaterials …, 2022 - pubs.rsc.org
Triple-negative breast cancer (TNBC) is characterized by rapid tumor growth and resistance
to cancer therapy, and has a poor prognosis. Accumulating data have revealed that cancer …

Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

J Jin, WS Lee, KM Joo, KK Maiti, G Biswas, W Kim… - …, 2011 - pubs.rsc.org
The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a
molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of …

Synthesis and cellular uptake properties of guanidine-containing molecular transporters built on the sucrose scaffold

WS Lee, CN Im, QY Teng, YT Chang, DC Kim… - Molecular …, 2009 - pubs.rsc.org
Woo Sirl Lee a , Chang-Nim Im b , Qi Ying Teng c , Young-Tae Chang bc , Dong-Chan
Kim d , Kyong-Tae Kim d and Sung-Kee Chung * a … PA Wender, WC Galliher, EA Goun …

Mitochondrial affinity of guanidine-rich molecular transporters built on monosaccharide scaffolds: stereochemistry and lipophilicity

WS Lee, WI Kim, KT Kim, SK Chung - Bulletin of the Korean …, 2011 - koreascience.kr
We synthesized eight G8 molecular transporters (MTs) based on 4 different monosaccharide
scaffolds, and studied their biological properties with a special focus on possible …

[PDF][PDF] Mitochondrial affinity of guanidine-rich molecular transporters built on myo-and scyllo-inositol scaffolds: stereochemistry dependency

SC Ghosh, BR Kim, JK Im, WS Lee, CN Im… - Bulletin of the Korean …, 2010 - academia.edu
Efficient drug delivery and good bioavailability at target tissues are important factors in the
new drug development, because many drug candidates with promising in vitro activity fail or …

Functional markers for bacterial blight resistance gene Xa3 in rice

…, JY Lee, YB Sohn, YC Song, DS Park, CW Lee… - Molecular …, 2013 - Springer
… We cloned and sequenced the Xa3/xa3 gene in the Korean cultivars Hwayeong, Ilmi, and
Goun and conferred resistance or susceptibility to BB. We detected polymorphisms, and …

[HTML][HTML] Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans

KT Lee, YS So, DH Yang, KW Jung, J Choi… - Nature …, 2016 - nature.com
Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis;
however, treatment options remain limited. Here we report the construction of 264 signature-…